Sadeghnia Alireza, Ganji Masoud, Armanian Amir Mohammad
Department of Pediatrics, School of Medicine and Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2014 Sep;5(9):1186-91.
Icter is the most prevalent disease in newborns. Although most of the newborns affiliated with this seem healthy in other aspects, there is always a fear for toxic complication of indirect hyperbilirobinemia in the central nervous system. Nowadays phototherapy is the method of decreasing (or avoidance of increase) of total serum bilirobin (TSB) and it is also used widely in neonatal health care centers according to the availably of equipment, but without any defined standard. In this study, two light sources, quarts halogen incandescent filament lamp (QHIFL) and fluorescent lamp (FL) are compared with each other to find out which method is more useful and efficient.
This study is a randomized controlled trial done on 25 newborns with gestational age of 35 weeks or more, with newborn's icter in the 1(st) week after birth, at Isfahan Behesti Hospital, February 2012 to March 2013. A group of these newborns was treated with FL and the other with QHIFL and they all were controlled and tested according to their level of TSB at the beginning of phototherapy, at 8(th), 12(th), and 24(th) h of treatment and at discharge. The data from the study was analyzed by IBM SPSS Statistics Version 21.
According to the findings, the level of TSB before and 8 h after the intervention had no significant difference among the groups. However, at 16(th) and 24(th) h of treatment, the TSB level was lower in the FL group and this difference was meaningful (P = 0.002 and P = 0.013 respectively). Furthermore the duration of the treatment was significantly shorter in FL group meaningfully (P = 0.047).
According to the findings of this study, the technology used in QHIFL cannot show the capabilities of the FLs. However, more studies are needed to confirm the findings of this study are universal.
黄疸是新生儿中最常见的疾病。尽管大多数患有黄疸的新生儿在其他方面看起来健康，但人们总是担心间接高胆红素血症在中枢神经系统中的毒性并发症。如今，光疗是降低（或避免升高）总血清胆红素（TSB）的方法，并且根据设备的可用性，它也在新生儿保健中心广泛使用，但没有任何明确的标准。在本研究中，比较了两种光源，石英卤素白炽灯丝灯（QHIFL）和荧光灯（FL），以找出哪种方法更有用和高效。
本研究是一项随机对照试验，于2012年2月至2013年3月在伊斯法罕贝赫斯蒂医院对25名孕周35周或以上、出生后第1周出现黄疸的新生儿进行。一组新生儿接受FL治疗，另一组接受QHIFL治疗，所有新生儿在光疗开始时、治疗第8、12和24小时以及出院时根据TSB水平进行对照和检测。研究数据采用IBM SPSS Statistics 21版进行分析。
根据研究结果，干预前和干预后8小时两组间TSB水平无显著差异。然而，在治疗第16和24小时，FL组的TSB水平较低，且这种差异具有统计学意义（分别为P = 0.002和P = 0.013）。此外，FL组的治疗持续时间明显更短，差异有统计学意义（P = 0.047）。
根据本研究结果，QHIFL所使用的技术无法展现出FL的性能。然而，需要更多研究来证实本研究结果具有普遍性。
