West R W, Rowland K L, Miller S A, Beer J Z
National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA.
Photodermatol Photoimmunol Photomed. 1995 Jun;11(3):119-23. doi: 10.1111/j.1600-0781.1995.tb00150.x.
The use of unfiltered quartz-halogen lamps exposes human skin to radiation that spans much of the ultraviolet (UV) spectrum. Reports indicate that exposure to quartz-halogen lamps is erythemogenic, mutagenic, and carcinogenic. To compare the carcinogenic potential of quartz-halogen lamps with that of other UV sources, we determined the dose dependence for cytotoxicity and neoplastic transformation in neonatal human fibroblasts exposed in vitro to: a 15 W germicidal lamp (primarily 254 nm radiation), a 15 W Cool White fluorescent lamp, and an unfiltered 20 W quartz-halogen lamp. Fluence-survival relationships were multiphasic with linear dose response below about 40% survival, and all three sources produced fluence-dependent transformation as indicated by induction of anchorage-independent growth. Maximum transformation frequencies were observed at fluences of 5-8 J/m2 for the germicidal lamp, 6.3 kJ/m2 for the fluorescent lamp, and 300 J/m2 for the quartz-halogen lamp. These data confirm the carcinogenic potential of the quartz-halogen lamp.
使用未经过滤的石英卤钨灯可使人体皮肤暴露于涵盖大部分紫外（UV）光谱的辐射中。报告表明，暴露于石英卤钨灯下会导致皮肤红斑、具有致突变性和致癌性。为了比较石英卤钨灯与其他紫外线源的致癌潜力，我们测定了体外暴露于以下光源的新生儿人成纤维细胞中细胞毒性和肿瘤转化的剂量依赖性：一盏15瓦杀菌灯（主要为254纳米辐射）、一盏15瓦冷白色荧光灯和一盏未经过滤的20瓦石英卤钨灯。通量-存活关系是多相的，在存活率低于约40%时呈线性剂量反应，并且所有三种光源都产生了通量依赖性转化，这通过非贴壁依赖性生长的诱导得以表明。杀菌灯在通量为5 - 8焦耳/平方米时观察到最大转化频率，荧光灯在6.3千焦耳/平方米时观察到最大转化频率，石英卤钨灯在300焦耳/平方米时观察到最大转化频率。这些数据证实了石英卤钨灯的致癌潜力。
