Taylor Robert M, Huber Dale L, Monson Todd C, Esch Victor, Sillerud Laurel O
University of New Mexico, Department of Biochemistry and Molecular Biology, MSC08 4670, 1 University of New Mexico, Albuquerque, New Mexico 87131 and New Mexico Cancer Nanoscience and Microsystems Training Center , Albuquerque, New Mexico 87106.
Sandia National Laboratories, Center for Integrated Nanotechnologies , P.O. Box 5800 MS 1304, Albuquerque, New Mexico 87111-1304.
J Vac Sci Technol B Nanotechnol Microelectron. 2012 Mar;30(2):02C101. doi: 10.1116/1.3692250. Epub 2012 Mar 5.
The authors report the synthesis, from simple salts, and the physical characterization of superparamagnetic iron platinum nanoparticles (SIPPs) suitable for use as contrast agents in magnetic resonance imaging. The properties of these particles were determined by means of transmission electron microscopy (TEM), thermogravimetric analysis, inductively coupled plasma-optical emission spectroscopy (ICP-OES), superconducting quantum interference device (SQUID) magnetometry, and nuclear magnetic resonance relaxivity at 4.7 T. TEM showed that the diameters of the particles ranged from 9.3 to 10 nm, depending on the mole ratio of iron to platinum precursors, and on the concentration of octadecylamine (ODA) used in their preparation. The iron to platinum stoichiometry determined by ICP-OES varied from 1.4:1 to 3.7:1 and was similarly dependent on the initial mole ratios of iron and platinum salts, as well as on the concentration of ODA in the reaction. SQUID magnetometry showed that the SIPPs were superparamagnetic and had magnetic moments that increased with increasing iron content from 62 to 72 A·m/kg Fe. The measured relaxivities of the SIPPs at 4.7 T were higher than commercially available superparamagnetic iron oxide nanoparticles, suggesting that these particles may be superior contrast agents in T-weighted magnetic resonance imaging.
作者报告了由简单盐类合成适用于磁共振成像造影剂的超顺磁性铁铂纳米颗粒（SIPPs）及其物理表征。通过透射电子显微镜（TEM）、热重分析、电感耦合等离子体发射光谱（ICP - OES）、超导量子干涉仪（SQUID）磁力测定以及在4.7 T下的核磁共振弛豫率来确定这些颗粒的性质。TEM显示，颗粒直径范围为9.3至10 nm，这取决于铁与铂前驱体的摩尔比以及制备过程中使用的十八胺（ODA）浓度。通过ICP - OES测定的铁与铂化学计量比在1.4:1至3.7:1之间变化，同样取决于铁盐和铂盐的初始摩尔比以及反应中ODA的浓度。SQUID磁力测定表明SIPPs具有超顺磁性，并且其磁矩随着铁含量从62增加到72 A·m/kg Fe而增大。在4.7 T下测量的SIPPs弛豫率高于市售超顺磁性氧化铁纳米颗粒，这表明这些颗粒可能是T加权磁共振成像中更优异的造影剂。
