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Bosentan for sarcoidosis-associated pulmonary hypertension, age-adjusted D-dimer levels in pulmonary embolism, and mean arterial blood pressure targets in septic shock.

作者信息

Alvarez Roger A, Barbash Ian J, Rose Jason J

机构信息

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

出版信息

Am J Respir Crit Care Med. 2014 Oct 15;190(8):948-9. doi: 10.1164/rccm.201407-1305RR.

DOI:10.1164/rccm.201407-1305RR
PMID:25317464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12042185/
Abstract
摘要

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1
Bosentan for sarcoidosis-associated pulmonary hypertension, age-adjusted D-dimer levels in pulmonary embolism, and mean arterial blood pressure targets in septic shock.波生坦用于结节病相关的肺动脉高压、肺栓塞中经年龄调整的D-二聚体水平以及感染性休克中的平均动脉血压目标。
Am J Respir Crit Care Med. 2014 Oct 15;190(8):948-9. doi: 10.1164/rccm.201407-1305RR.
2
The endothelin receptor antagonist, bosentan, in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock.内皮素受体拮抗剂波生坦与环氧化酶抑制剂双氯芬酸联合使用，可对抗猪内毒素休克中的肺动脉高压。
Crit Care Med. 1997 May;25(5):848-57. doi: 10.1097/00003246-199705000-00022.
3
Bosentan-improved cardiopulmonary vascular performance and increased plasma levels of endothelin-1 in porcine endotoxin shock.波生坦改善了猪内毒素休克时的心肺血管功能并提高了血浆内皮素-1水平。
Br J Pharmacol. 1996 Jun;118(3):617-26. doi: 10.1111/j.1476-5381.1996.tb15446.x.
4
Bosentan for sarcoidosis-associated pulmonary hypertension: a double-blind placebo controlled randomized trial.波生坦治疗结节病相关性肺动脉高压：一项双盲安慰剂对照随机试验。
Chest. 2014 Apr;145(4):810-817. doi: 10.1378/chest.13-1766.
5
Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock.内皮素受体拮抗剂波生坦可改善感染性休克患者内脏器官的微循环血流。
Crit Care Med. 2003 Jan;31(1):203-10. doi: 10.1097/00003246-200301000-00031.
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Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan.内皮素受体拮抗剂波生坦可有效对抗猪内毒素休克期间的心肺功能障碍。
Shock. 1997 May;7(5):364-70. doi: 10.1097/00024382-199705000-00009.
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Clin Respir J. 2018 Jun;12(6):2065-2074. doi: 10.1111/crj.12774. Epub 2018 Feb 22.
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Clinical efficacy and safety of switch from bosentan to macitentan in children and young adults with pulmonary arterial hypertension: extended study results.从波生坦转换为马昔腾坦治疗儿童和青少年肺动脉高压的临床疗效和安全性：扩展研究结果。
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Clinical efficacy and safety of switch from bosentan to macitentan in children and young adults with pulmonary arterial hypertension.在儿童和年轻成人肺动脉高压患者中从波生坦转换为马昔腾坦的临床疗效与安全性。
Cardiol Young. 2018 Apr;28(4):542-547. doi: 10.1017/S1047951117002542. Epub 2017 Dec 13.

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Sarcoidosis as a risk factor for venous thromboembolism.结节病作为静脉血栓栓塞的一个风险因素。
Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(2):170-178. doi: 10.36141/svdld.v34i2.4911. Epub 2017 Apr 28.
2
Venous thromboembolism and sarcoidosis: co-incidence or coexistence?静脉血栓栓塞症与结节病：巧合还是并存？
Cent Eur J Immunol. 2015;40(4):477-80. doi: 10.5114/ceji.2015.56972. Epub 2016 Jan 15.

本文引用的文献

1
Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study.年龄校正 D-二聚体界值排除肺栓塞：ADJUST-PE 研究。
JAMA. 2014 Mar 19;311(11):1117-24. doi: 10.1001/jama.2014.2135.
2
High versus low blood-pressure target in patients with septic shock.严重脓毒症及脓毒性休克患者的血压目标：高与低之比较
N Engl J Med. 2014 Apr 24;370(17):1583-93. doi: 10.1056/NEJMoa1312173. Epub 2014 Mar 18.
3
Treatment goals of pulmonary hypertension.肺动脉高压的治疗目标。
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D73-81. doi: 10.1016/j.jacc.2013.10.034.
4
Pulmonary hypertension in chronic lung diseases.慢性肺部疾病相关肺动脉高压。
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D109-16. doi: 10.1016/j.jacc.2013.10.036.
5
Bosentan for sarcoidosis-associated pulmonary hypertension: a double-blind placebo controlled randomized trial.波生坦治疗结节病相关性肺动脉高压：一项双盲安慰剂对照随机试验。
Chest. 2014 Apr;145(4):810-817. doi: 10.1378/chest.13-1766.
6
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.拯救脓毒症运动：严重脓毒症和脓毒性休克管理国际指南，2012 年。
Intensive Care Med. 2013 Feb;39(2):165-228. doi: 10.1007/s00134-012-2769-8. Epub 2013 Jan 30.
7
Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study.休克早期平均动脉压与肾功能的关系：一项前瞻性、探索性队列研究。
Crit Care. 2011;15(3):R135. doi: 10.1186/cc10253. Epub 2011 Jun 6.
8
Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts.年龄校正 D-二聚体截断值提高老年患者肺栓塞排除率的潜力：三个大型队列的回顾性分析。
BMJ. 2010 Mar 30;340:c1475. doi: 10.1136/bmj.c1475.
9
Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography.使用结合临床概率、D-二聚体检测和计算机断层扫描的算法管理疑似肺栓塞的有效性。
JAMA. 2006 Jan 11;295(2):172-9. doi: 10.1001/jama.295.2.172.