Geremek Anna Goljan, Tomkowski Witold, Geremek Marcin, Puścińska Elżbieta, Małek Grzegorz, Nowiński Adam, Bednarek Michal, Śliwiński Paweł
2nd Department of Respiratory Medicine, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Cardio-pulmonary Intensive Care, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.
Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(2):170-178. doi: 10.36141/svdld.v34i2.4911. Epub 2017 Apr 28.
Sarcoidosis as a chronic condition of immune dysregulation might be associated with increased risk of venous thromboembolism (VTE). In this study we report three cases of sarcoidosis and pulmonary embolism (PE) occurring together, that share common clinical, serological and pathological findings, confirming the diagnosis of active pulmonary sarcoidosis and no others co-existing prothrombotic factors. We hypothesized that the hypercoagulability and increased risk for VTE in sarcoidosis may be attributable to active local and generalized inflammatory process. The possible relation of clinical picture of sarcoidosis that favors thrombus formation and the bidirectional inflammation and coagulation process are discussed. Further investigation of PE in patients with sarcoidosis are required as the co-incidence of both diseases seems to be more frequent than expected. .
结节病作为一种免疫调节异常的慢性疾病，可能与静脉血栓栓塞（VTE）风险增加有关。在本研究中，我们报告了3例结节病与肺栓塞（PE）同时发生的病例，这些病例具有共同的临床、血清学和病理学表现，确诊为活动性肺结节病且无其他并存的血栓形成前因素。我们推测，结节病中的高凝状态及VTE风险增加可能归因于局部和全身的活动性炎症过程。本文讨论了有利于血栓形成的结节病临床表现与双向炎症和凝血过程之间可能存在的关系。由于这两种疾病的并存似乎比预期更常见，因此需要对结节病患者的PE进行进一步研究。
