Tain You-Lin, Huang Li-Tung, Chan Julie Y H
Departments of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Int J Mol Sci. 2014 Oct 14;15(10):18484-95. doi: 10.3390/ijms151018484.
Melatonin is an endogenously produced indoleamine and secreted by the pineal gland. Melatonin has pleiotropic bioactivities and is involved in epigenetic regulation. Suboptimal conditions during maternal and perinatal phases can elicit epigenetic regulation of genes for nephrogenesis and reset physiological responses to develop programmed hypertension. This review discusses the early utility of melatonin to prevent programmed hypertension in later life by epigenetic regulation in the kidney, with an emphasis on: (1) the role of melatonin in epigenetic regulation; (2) the beneficial effects of melatonin on programmed hypertension; (3) epigenetic regulation of maternal melatonin therapy in different developmental windows of offspring kidneys analyzed by whole-genome RNA next-generation sequencing; and (4) current blocks in the application of melatonin in preventing programmed hypertension.
褪黑素是一种内源性产生的吲哚胺，由松果体分泌。褪黑素具有多种生物活性，并参与表观遗传调控。母婴期和围生期的不良状况可引发肾发生相关基因的表观遗传调控，并重置生理反应以发展为程序性高血压。本综述讨论了褪黑素通过肾脏中的表观遗传调控预防后期生活中程序性高血压的早期效用，重点关注：（1）褪黑素在表观遗传调控中的作用；（2）褪黑素对程序性高血压的有益作用；（3）通过全基因组RNA下一代测序分析母体褪黑素治疗对后代肾脏不同发育窗口的表观遗传调控；以及（4）目前褪黑素在预防程序性高血压应用中的障碍。
