Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Molecules. 2018 Apr 11;23(4):886. doi: 10.3390/molecules23040886.
Consumption of food high in fructose and salt is associated with the epidemic of hypertension. Hypertension can originate from early life. Melatonin, a pleiotropic hormone, regulates blood pressure. We examined whether maternal melatonin therapy can prevent maternal high-fructose combined with post-weaning high-salt diet-induced programmed hypertension in adult offspring. Pregnant Sprague-Dawley rats received either a normal diet (ND) or a 60% fructose diet (HF) during pregnancy and the lactation period. Male offspring were on either the ND or a high-salt diet (HS, 1% NaCl) from weaning to 12 weeks of age and were assigned to five groups (n = 8/group): ND/ND, HF/ND, ND/HS, HF/HS, and HF/HS+melatonin. Melatonin (0.01% in drinking water) was administered during pregnancy and lactation. We observed that maternal HF combined with post-weaning HS diets induced hypertension in male adult offspring, which was attenuated by maternal melatonin therapy. The beneficial effects of maternal melatonin therapy on HF/HS-induced hypertension related to regulating several nutrient-sensing signals, including , , , , , and . Additionally, melatonin increased protein levels of mammalian targets of rapamycin (mTOR), decreased plasma asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine levels, and increased the l-arginine-to-ADMA ratio. The reprogramming effects by which maternal melatonin therapy protects against hypertension of developmental origin awaits further elucidation.
高果糖和高盐食物的消耗与高血压流行有关。高血压可能起源于生命早期。褪黑素作为一种多效激素，可调节血压。我们研究了母体褪黑素治疗是否可以预防母体高果糖与断奶后高盐饮食引起的成年后代程序性高血压。怀孕的 Sprague-Dawley 大鼠在怀孕期间和哺乳期接受正常饮食（ND）或 60%果糖饮食（HF）。雄性后代从断奶到 12 周龄接受 ND 或高盐饮食（HS，1%NaCl），并分为五组（n = 8/组）：ND/ND、HF/ND、ND/HS、HF/HS 和 HF/HS+褪黑素。在怀孕期间和哺乳期给予褪黑素（饮用水中 0.01%）。我们观察到，母体 HF 与断奶后 HS 饮食联合使用会在雄性成年后代中引起高血压，而母体褪黑素治疗可减轻这种高血压。母体褪黑素治疗对 HF/HS 诱导的高血压的有益作用与调节几种营养感应信号有关，包括、、、、、和。此外，褪黑素增加了雷帕霉素靶蛋白（mTOR）的蛋白水平，降低了血浆不对称二甲基精氨酸（ADMA）和对称二甲基精氨酸水平，并增加了 l-精氨酸与 ADMA 的比值。母体褪黑素治疗预防发育起源高血压的重编程作用有待进一步阐明。
