Department of Obstetrics/Gynecology, Molecular Biology Laboratory, University Hospital Munich, Maistrasse 11, 80337, Munich, Germany,
Cancer Metastasis Rev. 2014 Dec;33(4):943-51. doi: 10.1007/s10555-014-9520-6.
The family of metastasis-associated (MTA) genes is a small group of transcriptional co-regulators which are involved in various physiological functions, ranging from lymphopoietic cell differentiation to the development and maintenance of epithelial cell adhesions. By recruiting histone-modifying enzymes to specific promoter sequences, MTA proteins can function both as transcriptional repressors and activators of a number of cancer-relevant proteins, including Snail, E-cadherin, signal transducer and activator of transcriptions (STATs), and the estrogen receptor. Their involvement in the epithelial-mesenchymal transition process and regulatory interactions with estrogen receptor activity has made MTA proteins highly interesting research candidates, especially in the field of hormone-sensitive breast cancer and malignancies of the female reproductive tract. This review focuses on the current knowledge about the function and regulation of MTA1 and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors.
转移相关（MTA）基因家族是一小群转录共调节剂，参与各种生理功能，从淋巴造血细胞分化到上皮细胞黏附的发育和维持。MTA 蛋白通过将组蛋白修饰酶募集到特定的启动子序列，可以作为许多与癌症相关蛋白的转录抑制剂和激活剂发挥作用，包括 Snaill、E-钙黏蛋白、信号转导和转录激活因子（STATs）和雌激素受体。它们参与上皮-间充质转化过程，并与雌激素受体活性进行调节相互作用，使得 MTA 蛋白成为非常有趣的研究候选物，特别是在激素敏感型乳腺癌和女性生殖道恶性肿瘤领域。这篇综述重点介绍了 MTA1 和 MTA3 蛋白在妇科癌症（包括卵巢癌、子宫内膜癌和宫颈癌）中的功能和调节的最新知识。
