Aggarwal Amitesh, Aggarwal Sourabh, Sharma Vishal
Department of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, India.
J Cardiovasc Thorac Res. 2014;6(3):169-73. doi: 10.15171/jcvtr.2014.006. Epub 2014 Sep 30.
Studies evaluating temporal trends of Coronary artery disease (CAD) in young patients, from the India, are still lacking. The aim of this study was to evaluate temporal differences in risk factors of young patients of CAD over a decade.
This is a single centre retrospective study performed in a tertiary care teaching institution in North India. Case records of young patients (≤40 years) with acute coronary syndrome between January 2000 to December 2001 and January 2009 to December 2010 were obtained. Records were sought for active smoking, family history, waist size, blood pressure, hypertension, fasting and postprandial blood sugar and lipid profile for both groups and analyzed using SPSS v.17. For the purpose of the study, p value <0.05 was considered statistically significant.
Medical records of a total of 79 and 83 patients with young CAD (≤40 years) were obtained for 2000-01 and 2009-10 period respectively. An increase in proportion of female patients, hypertension (p=0.004), dysglycemia (p<0.001), family history (p=0.01), metabolic syndrome (p<0.001), low high density lipoprotein (HDL) (p=0.07) and mean waist size (0.03) was noted over the years. Among males, increase in number of dysglycemics (p=0.0002), positive family history (p<0.0001) and mean waist size (0.032) was statistically significant.
Over a decade the patients with young CAD in our study, there was an increase in proportion of patients with metabolic syndrome, dysglycemia and low HDL.
在印度，评估年轻患者冠状动脉疾病（CAD）时间趋势的研究仍然缺乏。本研究的目的是评估十年间年轻CAD患者危险因素的时间差异。
这是一项在印度北部一家三级护理教学机构进行的单中心回顾性研究。获取了2000年1月至2001年12月以及2009年1月至2010年12月期间年轻患者（≤40岁）急性冠状动脉综合征的病例记录。查找两组患者的主动吸烟、家族史、腰围、血压、高血压、空腹及餐后血糖和血脂谱，并使用SPSS v.17进行分析。为了本研究的目的，p值<0.05被认为具有统计学意义。
分别获得了2000 - 01年和2009 - 10年期间总共79例和83例年轻CAD（≤40岁）患者的病历。多年来，女性患者比例、高血压（p = 0.004）、血糖异常（p < 0.001）、家族史（p = 0.01）、代谢综合征（p < 0.001）、低高密度脂蛋白（HDL）（p = 0.07）和平均腰围（0.03）均有所增加。在男性中，血糖异常患者数量（p = 0.0002）、阳性家族史（p < 0.0001）和平均腰围（0.032）的增加具有统计学意义。
在我们研究的十年间，年轻CAD患者中代谢综合征、血糖异常和低HDL患者的比例有所增加。
