抗CD45RA抗体通过白细胞介素2/白细胞介素2受体途径增加小鼠T细胞对植物血凝素的增殖反应。
Anti-CD45RA antibodies increase the proliferation of mouse T cells to phytohemagglutinin through the interleukin 2/interleukin 2 receptor pathway.
作者信息
Marvel J, Poirier G, Lightstone E
机构信息
Department of Biology, University College, London.
出版信息
Eur J Immunol. 1989 Nov;19(11):2005-10. doi: 10.1002/eji.1830191106.
PMID:2532137
Abstract
We have studied the effect of anti-CD45RA monoclonal antibodies on the proliferation of murine spleen T cells activated with phytohemagglutinin. Antibodies act on both CD8 and CD4 subsets of T cells. They seem to replace a signal normally delivered by accessory cells which would act through the interleukin 2/interleukin 2 receptor pathway.
摘要
我们研究了抗CD45RA单克隆抗体对用植物血凝素激活的小鼠脾脏T细胞增殖的影响。抗体作用于T细胞的CD8和CD4亚群。它们似乎替代了通常由辅助细胞传递的信号，辅助细胞会通过白细胞介素2/白细胞介素2受体途径发挥作用。
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