Zhan Ping, Li Zhi-hua, Geng Chengfang, Jiang Qing, Jin Yun, Dolatabadi Somayeh, Liu Weida, de Hoog G Sybren
Specialized Dermatology Hospital of Jiangxi Province, Nanchang, China.
Mycopathologia. 2015 Feb;179(1-2):159-61. doi: 10.1007/s11046-014-9823-8. Epub 2014 Oct 17.
A 48-year-old female had presented dandruff and breakable hair for more than 40 years, dry scaly erythema on bilateral palms and feet accompanying with nail destruction for 20 years, and scaling papules on the buttock for 5 years. Direct microscopic examination showed endothrix anthroconidia within broken hair and septate and branched hyphae within skin and nail lesion. Fungal cultures from all infected sites were examined by morphology, ITS sequencing, and random amplified polymorphic DNA fingerprinting, and were identified as Trichophyton violaceum from the same source. The patient was treated with oral terbinafine 0.25 g/day as well as with 1% terbinafine gel for external use and with 2% ketoconazole lotion for shampoo and bath. A follow-up after 4 weeks showed that the lesions decreased significantly.
一名48岁女性出现头皮屑和头发易折断40多年，双侧手掌和足部有干燥鳞屑性红斑并伴有指甲损害20年，臀部有鳞屑性丘疹5年。直接镜检显示断发内有发内型小孢子菌，皮肤和指甲损害内有分隔和分支的菌丝。对所有感染部位进行真菌培养，并通过形态学、ITS测序和随机扩增多态性DNA指纹分析进行检测，结果均鉴定为来自同一来源的紫色毛癣菌。患者接受口服特比萘芬0.25g/天治疗，同时外用1%特比萘芬凝胶，并用2%酮康唑洗剂洗头和洗澡。4周后随访显示皮损明显减轻。
