Wang Ping-Ping, He Xiao-Yan, Wang Robin, Wang Zengfang, Wang Yan-Gang
Department of Obstetrics, Maternal and Child Health Hospital of Weifang, Weifang, China.
Cell Physiol Biochem. 2014;34(5):1477-84. doi: 10.1159/000366352. Epub 2014 Oct 8.
BACKGROUND/AIMS: Previous studies suggested that high leptin level might increase risk of endometrial cancer, but available data were conflicting and whether high leptin level was an independent risk factor of endometrial cancer was still unclear. Therefore, a meta-analysis was performed to assess whether high leptin level was an independent risk factor of endometrial cancer.
PubMed, Web of Science, and Embase databases were searched for epidemiological studies published up to June 26, 2014. The pooled risk ratio (RR) with 95% confidence interval (95%CI) was used to assess the association between leptin level and risk of endometrial cancer.
Six studies with a total of 3136 individuals were finally included into the meta-analysis. Meta-analysis of total 6 studies showed that high leptin level was associated with increased risk of endometrial cancer (RR = 2.55, 95%CI 1.91-3.41, P < 0.001). After adjusting for confounding factors, high leptin level was also associated with increased risk of endometrial cancer (RR =1.59, 95%CI 1.27-1.98, P < 0.001). Sensitivity analysis proved the stability of the pooled estimates. The RR of endometrial cancer was 1.10 (95%CI, 1.03-1.18, P = 0.005) per 5 ng/mL increment in leptin levels. There was no obvious risk of publication bias (P Egger = 0.54).
Our findings suggest that high leptin level is an independent risk factor of endometrial cancer. More prospective studies are needed to further confirm the association in the future.
背景/目的：既往研究提示高瘦素水平可能增加子宫内膜癌风险，但现有数据存在矛盾，高瘦素水平是否为子宫内膜癌的独立危险因素仍不明确。因此，进行了一项荟萃分析以评估高瘦素水平是否为子宫内膜癌的独立危险因素。
检索了PubMed、Web of Science和Embase数据库中截至2014年6月26日发表的流行病学研究。采用合并风险比（RR）及95%置信区间（95%CI）评估瘦素水平与子宫内膜癌风险之间的关联。
最终6项研究共3136例个体纳入荟萃分析。对6项研究的荟萃分析显示，高瘦素水平与子宫内膜癌风险增加相关（RR = 2.55，95%CI 1.91 - 3.41，P < 0.001）。校正混杂因素后，高瘦素水平仍与子宫内膜癌风险增加相关（RR = 1.59，95%CI 1.27 - 1.98，P < 0.001）。敏感性分析证实了合并估计值的稳定性。瘦素水平每增加5 ng/mL，子宫内膜癌的RR为1.10（95%CI，1.03 - 1.18，P = 0.005）。无明显发表偏倚风险（P埃格检验 = 0.54）。
我们的研究结果提示高瘦素水平是子宫内膜癌的独立危险因素。未来需要更多前瞻性研究进一步证实这种关联。
