Brzecka Anna, Martynowicz Helena, Daroszewski Cyryl, Majchrzak Maciej, Ejma Maria, Misiuk-Hojło Marta, Somasundaram Siva G, Kirkland Cecil E, Kosacka Monika
Department of Pulmonology and Lung Oncology, Wroclaw Medical University, Grabiszyńska 105, 53-439 Wroclaw, Poland.
Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
J Clin Med. 2023 Apr 2;12(7):2655. doi: 10.3390/jcm12072655.
Obesity and sarcopenia, i.e., decreased skeletal muscle mass and function, are global health challenges. Moreover, people with obesity and sedentary lifestyles often have sleep disorders. Despite the potential associations, metabolic disturbances linking obesity, sarcopenia, and sleep disorders with cancer are neither well-defined nor understood fully. Abnormal levels of adipokines and adipomyokines originating from both adipose tissue and skeletal muscles are observed in some patients with obesity, sarcopenia and sleep disorders, as well as in cancer patients. This warrants investigation with respect to carcinogenesis. Adipokines and adipomyokines may exert either pro-carcinogenic or anti-carcinogenic effects. These factors, acting independently or together, may significantly modulate the incidence and progression of cancer. This review indicates that one of the possible pathways influencing the development of cancer may be the mutual relationship between obesity and/or sarcopenia, sleep quantity and quality, and adipokines/adipomyokines excretion. Taking into account the high proportion of persons with obesity and sedentary lifestyles, as well as the associations of these conditions with sleep disturbances, more attention should be paid to the individual and combined effects on cancer pathophysiology.
肥胖和肌肉减少症，即骨骼肌质量和功能下降，是全球性的健康挑战。此外，肥胖且久坐不动的人往往存在睡眠障碍。尽管存在潜在关联，但将肥胖、肌肉减少症和睡眠障碍与癌症联系起来的代谢紊乱既未得到明确界定，也未被完全理解。在一些肥胖、肌肉减少症和睡眠障碍患者以及癌症患者中，观察到源自脂肪组织和骨骼肌的脂肪因子和脂肪肌因子水平异常。这就需要对致癌作用进行研究。脂肪因子和脂肪肌因子可能发挥促癌或抗癌作用。这些因素单独或共同作用，可能会显著调节癌症的发生和发展。本综述表明，影响癌症发展的一条可能途径可能是肥胖和/或肌肉减少症、睡眠数量和质量以及脂肪因子/脂肪肌因子排泄之间的相互关系。考虑到肥胖和久坐不动人群的比例较高，以及这些情况与睡眠障碍的关联，应更加关注它们对癌症病理生理学的个体和综合影响。
