Rudroff T, Kindred J H, Koo P J, Karki R, Hebert J R
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
Department of Radiology, University of Colorado School of Medicine, Aurora, CO, USA.
NeuroRehabilitation. 2014;35(4):813-23. doi: 10.3233/NRE-141179.
In patients with Multiple Sclerosis (MS), comparative leg muscle strength asymmetries are common and typically accompanied by walking difficulties. Underlying mechanisms for these asymmetries are not completely known, but altered muscle energetics may play a role.
To investigate glucose uptake asymmetries in leg muscles of patients with mild MS during walking.
Eight MS and 8 healthy control (CON) participants performed a 15-min treadmill walking test at self-selected speed. They were injected with a glucose tracer (18F-FDG) two minutes into the test and immediately upon completion, underwent Positron Emission Tomography/Computed Tomography (PET/CT) imaging.
MS group walked at a lower speed than the healthy control group (P < 0.01), however it was found that: 1) ([18F]-FDG) uptake in knee and hip flexors was higher compared to the CON group (P = 0.02); 2) the MS group exhibited asymmetrical strength of the knee flexors (P = 0.03); 3) [18F]-FDG uptake was significantly lower in the weaker knee flexors of patients with MS (P < 0.01).
[18F]-FDG uptake and strength asymmetries in the legs of patients with MS indicate greater metabolic costs during activity, which may play a major role in premature muscle fatigability and subsequent impaired walking capacity.
在多发性硬化症（MS）患者中，腿部肌肉力量的比较性不对称很常见，并且通常伴有行走困难。这些不对称的潜在机制尚不完全清楚，但肌肉能量代谢的改变可能起了一定作用。
研究轻度MS患者在行走过程中腿部肌肉的葡萄糖摄取不对称情况。
8名MS患者和8名健康对照（CON）参与者以自选速度进行了15分钟的跑步机行走测试。在测试开始两分钟时给他们注射葡萄糖示踪剂（18F-FDG），测试一结束就立即进行正电子发射断层扫描/计算机断层扫描（PET/CT）成像。
MS组的行走速度低于健康对照组（P < 0.01），然而发现：1）与CON组相比，膝关节和髋关节屈肌中的（[18F]-FDG）摄取更高（P = 0.02）；2）MS组表现出膝关节屈肌力量不对称（P = 0.03）；3）MS患者较弱的膝关节屈肌中的[18F]-FDG摄取显著更低（P < 0.01）。
MS患者腿部的[18F]-FDG摄取和力量不对称表明活动期间代谢成本更高，这可能在肌肉过早疲劳和随后的行走能力受损中起主要作用。
