Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Contrast Media Mol Imaging. 2018 Jun 5;2018:1382183. doi: 10.1155/2018/1382183. eCollection 2018.
Molecular imaging has emerged at the end of the last century as an interdisciplinary method involving imaging and molecular biology aiming at identifying living biological processes at a cellular and molecular level in a noninvasive manner. It has a profound role in determining disease changes and facilitating drug research and development, thus creating new medical modalities to monitor human health. At present, a variety of different molecular imaging techniques have their advantages, disadvantages, and limitations. In order to overcome these shortcomings, researchers combine two or more detection techniques to create a new imaging mode, such as multimodal molecular imaging, to obtain a better result and more information regarding monitoring, diagnosis, and treatment. In this review, we first describe the classic molecular imaging technology and its key advantages, and then, we offer some of the latest multimodal molecular imaging modes. Finally, we summarize the great challenges, the future development, and the great potential in this field.
分子影像学是上个世纪末出现的一种涉及影像学和分子生物学的交叉学科方法，旨在非侵入性地在细胞和分子水平上识别活体的生物学过程。它在确定疾病变化、促进药物研发方面具有重要作用，从而创造了新的医学模式来监测人类健康。目前，各种不同的分子影像学技术都有其优缺点和局限性。为了克服这些缺点，研究人员将两种或更多种检测技术结合起来，创造出新的成像模式，如多模态分子成像，以获得更好的结果和更多关于监测、诊断和治疗的信息。在这篇综述中，我们首先描述了经典的分子成像技术及其关键优势，然后介绍了一些最新的多模态分子成像模式。最后，我们总结了该领域面临的巨大挑战、未来发展和巨大潜力。
