Bell Jared A, Wolke Malerie L, Ortez Ryan C, Jones Theresa A, Kerr Abigail L
University of Texas at Austin, TX, USA.
Illinois Wesleyan University, Bloomington IL, USA
Neurorehabil Neural Repair. 2015 Jul;29(6):590-8. doi: 10.1177/1545968314553031. Epub 2014 Oct 16.
Motor rehabilitative training improves behavioral functionality and promotes beneficial neural reorganization following stroke but is often insufficient to normalize function. Rodent studies have relied on skilled reaching tasks to model motor rehabilitation and explore factors contributing to its efficacy. It has been found that greater training intensity (sessions/day) and duration (training days) facilitates motor skill learning in intact animals. Whether rehabilitative training efficacy varies with intensity following stroke is unclear.
Mice were trained preoperatively on a skilled reaching task. Following focal ischemic lesions, mice received rehabilitative training either twice daily (high intensity [HI]), once daily (low intensity [LI]), or not at all (control) to determine the effects of rehabilitative training intensity on skilled motor performance.
Within 7 days, the HI-trained mice achieved preischemic levels of performance. Mice receiving LI training eventually reached similar performance levels but required a greater quantity of training. Training intensity did not consistently affect the maintenance of performance gains, which were partially lost over time in both groups.
These data indicate that increased training intensity increases the rate of functional improvements per time and per training session following ischemic insult. Thus, training intensity is an important variable to consider in efforts to optimize rehabilitation efficacy.
运动康复训练可改善行为功能，并促进中风后有益的神经重组，但通常不足以使功能恢复正常。啮齿动物研究依靠熟练的抓握任务来模拟运动康复，并探索影响其疗效的因素。已发现更高的训练强度（每天训练次数）和持续时间（训练天数）有助于完整动物的运动技能学习。中风后康复训练的疗效是否随强度变化尚不清楚。
术前对小鼠进行熟练抓握任务训练。局灶性缺血性损伤后，小鼠分别接受每日两次（高强度 [HI]）、每日一次（低强度 [LI]）的康复训练或不接受训练（对照组），以确定康复训练强度对熟练运动表现的影响。
7天内，接受HI训练的小鼠达到了缺血前的表现水平。接受LI训练的小鼠最终达到了相似的表现水平，但需要更多的训练量。训练强度并未始终影响表现增益的维持，两组的表现增益随时间均有部分丧失。
这些数据表明，增加训练强度可提高缺血性损伤后每次训练和每次训练时间内功能改善的速率。因此，在努力优化康复疗效时，训练强度是一个需要考虑的重要变量。
