Berdanier C D, McIntosh M K
Department of Foods and Nutrition, University of Georgia, Athens 30602.
Proc Soc Exp Biol Med. 1989 Dec;192(3):242-7. doi: 10.3181/00379727-192-42992.
Two experiments were conducted to determine the effects of dehydroepiandrosterone (DHEA) on de novo fatty acid synthesis and oxygen consumption in BHE rats fed a 65% glucose diet. In Experiment 1, starved glucose-refed rats were injected ip with 120 mg of DHEA/kg body wt and hepatic de novo fatty acid synthesis was measured. DHEA-treated rats synthesized less fatty acid in response to starvation refeeding than nontreated rats. In Experiment 2, weanling rats were fed the glucose diet for 4 weeks. One-hundred twenty milligrams of DHEA/kg were injected daily for 3 weeks. Body weight gain, epididymal fat pad weight, and carcass lipid were less in the DHEA-treated rats than in the control rats. Mitochondrial respiration was less and liver size was greater in DHEA-treated rats compared with control rats. Whole body oxygen consumption was increased in DHEA-treated rats, suggesting that this steroid might be stimulating futile energy cycles involving lipid and protein turnover possibly through its effect on glucocorticoid and thyroid hormone function.
进行了两项实验，以确定脱氢表雄酮（DHEA）对喂食65%葡萄糖饮食的BHE大鼠从头脂肪酸合成和氧消耗的影响。在实验1中，对饥饿后再喂食葡萄糖的大鼠腹腔注射120mg/kg体重的DHEA，并测量肝脏从头脂肪酸合成。与未处理的大鼠相比，DHEA处理的大鼠在饥饿再喂食后合成的脂肪酸较少。在实验2中，给断奶大鼠喂食葡萄糖饮食4周。每天注射120mg/kg的DHEA，持续3周。与对照大鼠相比，DHEA处理的大鼠体重增加、附睾脂肪垫重量和胴体脂质较少。与对照大鼠相比，DHEA处理的大鼠线粒体呼吸较少，肝脏体积较大。DHEA处理的大鼠全身氧消耗增加，这表明这种类固醇可能通过其对糖皮质激素和甲状腺激素功能的影响，刺激涉及脂质和蛋白质周转的无效能量循环。
