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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

McIntosh M K, Pan J S, Berdanier C D

Department of Food, Nutrition, University of North Carolina, Greensboro 27412.

Comp Biochem Physiol Comp Physiol. 1993 Jan;104(1):147-53. doi: 10.1016/0300-9629(93)90022-v.

The in vitro effects of dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEA-S) and related steroids on glucocorticoid corticosterone (GC) binding in hepatic cytosol and hepatic mitochondrial respiration were examined in male BHE/cdb and Sprague-Dawley (SD) rats. 2. The Kd and the IC50 for GC binding in SD rats were 5- and 2-fold higher, respectively, than in BHE/cdb rats. 3. Hepatic cytosol from BHE/cdb rats bound six times more [3H]-GC to receptors than that from SD rats. 4. The percentage displacement and Bmax of GC for its receptors were similar for the two strains of rats. 5. DHEA and DHEA-S did not displace GC from its receptors. 6. DHEA and related non-sulfated steroids decreased state 3 mitochondrial respiration, respiratory control and oxidative phosphorylation capacity in a dose-dependent manner with malate + pyruvate as substrate.

在雄性BHE/cdb和Sprague-Dawley（SD）大鼠中，检测了脱氢表雄酮（DHEA）、硫酸脱氢表雄酮（DHEA-S）及相关类固醇对肝细胞溶质中糖皮质激素皮质酮（GC）结合以及肝线粒体呼吸的体外作用。2. SD大鼠中GC结合的解离常数（Kd）和半数抑制浓度（IC50）分别比BHE/cdb大鼠高5倍和2倍。3. BHE/cdb大鼠的肝细胞溶质与受体结合的[3H]-GC比SD大鼠的多6倍。4. 两种品系大鼠中GC与其受体的置换百分比和最大结合容量（Bmax）相似。5. DHEA和DHEA-S不会从其受体上置换GC。6. 以苹果酸+丙酮酸为底物时，DHEA和相关的非硫酸化类固醇以剂量依赖方式降低线粒体呼吸状态3、呼吸控制和氧化磷酸化能力。

McIntosh M K, Pan J S, Berdanier C D

Department of Food, Nutrition, University of North Carolina, Greensboro 27412.

Comp Biochem Physiol Comp Physiol. 1993 Jan;104(1):147-53. doi: 10.1016/0300-9629(93)90022-v.

The in vitro effects of dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEA-S) and related steroids on glucocorticoid corticosterone (GC) binding in hepatic cytosol and hepatic mitochondrial respiration were examined in male BHE/cdb and Sprague-Dawley (SD) rats. 2. The Kd and the IC50 for GC binding in SD rats were 5- and 2-fold higher, respectively, than in BHE/cdb rats. 3. Hepatic cytosol from BHE/cdb rats bound six times more [3H]-GC to receptors than that from SD rats. 4. The percentage displacement and Bmax of GC for its receptors were similar for the two strains of rats. 5. DHEA and DHEA-S did not displace GC from its receptors. 6. DHEA and related non-sulfated steroids decreased state 3 mitochondrial respiration, respiratory control and oxidative phosphorylation capacity in a dose-dependent manner with malate + pyruvate as substrate.

在雄性BHE/cdb和Sprague-Dawley（SD）大鼠中，检测了脱氢表雄酮（DHEA）、硫酸脱氢表雄酮（DHEA-S）及相关类固醇对肝细胞溶质中糖皮质激素皮质酮（GC）结合以及肝线粒体呼吸的体外作用。2. SD大鼠中GC结合的解离常数（Kd）和半数抑制浓度（IC50）分别比BHE/cdb大鼠高5倍和2倍。3. BHE/cdb大鼠的肝细胞溶质与受体结合的[3H]-GC比SD大鼠的多6倍。4. 两种品系大鼠中GC与其受体的置换百分比和最大结合容量（Bmax）相似。5. DHEA和DHEA-S不会从其受体上置换GC。6. 以苹果酸+丙酮酸为底物时，DHEA和相关的非硫酸化类固醇以剂量依赖方式降低线粒体呼吸状态3、呼吸控制和氧化磷酸化能力。