Werther Tobias, Olischar Monika, Giordano Vito, Czaba Christine, Waldhoer Thomas, Berger Angelika, Pollak Arnold, Deindl Philipp
Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
Neonatology. 2015;107(1):34-41. doi: 10.1159/000365277. Epub 2014 Oct 10.
The lower margin amplitude (LMA) of the amplitude-integrated electroencephalogram (aEEG) is suppressed in neonates during deep sedation, a feature that is attributed to the bispectral index (BIS) in adults.
We compare the BIS and the LMA of the aEEG in neonates.
Thirty neurologically healthy neonates between 37 and 44 weeks postmenstrual age were included in this study. Twenty patients received sedoanalgesic therapy for various reasons. BIS and aEEG recordings were performed simultaneously. The digital data were imported in the numerical software environment Matlab®. The LMA of the aEEG was computed on a 1-min time scale and synchronized with the BIS data. The correlation between the time-dependent variables BIS and LMA was estimated using the Spearman rank correlation index.
The median correlation between BIS and LMA was 0.3. Inclusion of recordings of high signal quality only into analysis improved the median correlation index to 0.6.
We found a light-to-moderate correlation between BIS and LMA in our study cohort and a good correlation in the subgroup with high signal quality.
在深度镇静期间，新生儿的振幅整合脑电图（aEEG）的下缘振幅（LMA）受到抑制，这一特征在成人中归因于脑电双频指数（BIS）。
我们比较新生儿的BIS和aEEG的LMA。
本研究纳入了30名孕龄在37至44周之间的神经功能正常的新生儿。20名患者因各种原因接受了镇静镇痛治疗。同时进行BIS和aEEG记录。数字数据被导入数值软件环境Matlab®。aEEG的LMA在1分钟的时间尺度上计算，并与BIS数据同步。使用Spearman等级相关指数估计时间相关变量BIS和LMA之间的相关性。
BIS和LMA之间的中位数相关性为0.3。仅将高信号质量的记录纳入分析可将中位数相关指数提高到0.6。
在我们的研究队列中，我们发现BIS和LMA之间存在轻度至中度的相关性，在高信号质量的亚组中存在良好的相关性。
