Shin Won-Ho, Ri Yu, Do Seon-Gil, Lee Young-Chul, Park Sang-Joon
Department of Histology, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
Unigen Inc., Cheonan, Korea.
Lab Anim Res. 2014 Sep;30(3):112-22. doi: 10.5625/lar.2014.30.3.112. Epub 2014 Sep 29.
UG0712 is a new ginsenoside extract processed from ginseng leaves. A subchronic toxicity study of UG0712 was conducted in male and female SD rats. Rats were treated with UG0712 at doses of 100, 400 and 1,600 mg/kg/day for 13 weeks, and observed followed by 4-week recovery period at a highest dose. No-treatment-related effects were observed regarding the mortality, ophthalmic examination, urinalysis and histopathology. Although the changes in clinical sign, body weight, organ weight, hematology, and serum biochemistry were observed, they were temporal and pharmacological effects. Based on the present experiment conditions, the no observed adverse effect level was considered to be more than 1,600 mg/kg/day in both sexes of rats.
UG0712是一种从人参叶中提取的新型人参皂苷提取物。对雄性和雌性SD大鼠进行了UG0712的亚慢性毒性研究。大鼠以100、400和1600mg/kg/天的剂量接受UG0712治疗，持续13周，并在最高剂量下观察4周的恢复期。在死亡率、眼科检查、尿液分析和组织病理学方面未观察到与治疗相关的影响。虽然观察到临床症状、体重、器官重量、血液学和血清生物化学的变化，但这些都是暂时的药理作用。根据目前的实验条件，大鼠两性的未观察到不良反应水平均被认为超过1600mg/kg/天。
