DasGupta Riddhi, Shetty Sahana, Keshava Shyamkumar Nidugala, Gupta Mayank, Paul Mazhuvanchary Jacob, Thomas Nihal
Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India.
Department of Radiology, Christian Medical College, Vellore, India.
Australas Med J. 2014 Sep 30;7(9):372-5. doi: 10.4066/AMJ.2014.2084. eCollection 2014.
Parathyroid carcinoma (PCA), accounting for less than one per cent of all endocrine malignancies, is a rare cause of primary hyperparathyroidism. A diagnosis of parathyroid carcinoma may be challenging in the presence of localised disease and involves a histological diagnosis based on capsular, vascular, or perineural invasion or the presence of metastasis. Distant metastasis remains a rare presentation, with the lung being the most common site. Surgery remains the treatment of choice as radiotherapy and chemotherapy have proved to be of limited benefit in metastatic disease. This case reports suggests that radiofrequency ablation has the potential to be a novel and effective treatment option in these patients.
甲状旁腺癌（PCA）占所有内分泌恶性肿瘤的比例不到1%，是原发性甲状旁腺功能亢进的罕见病因。在存在局限性疾病的情况下，甲状旁腺癌的诊断可能具有挑战性，需要基于包膜、血管或神经周围侵犯或转移情况进行组织学诊断。远处转移仍然是一种罕见的表现，肺是最常见的转移部位。手术仍然是首选治疗方法，因为放疗和化疗在转移性疾病中的疗效有限。本病例报告表明，射频消融有可能成为这些患者的一种新型有效治疗选择。
