Wilcox James A, Quadri Syed
Department of Psychiatry, University of Arizona, Tucson, Arizona, USA.
Psychiatr Genet. 2014 Dec;24(6):266-8. doi: 10.1097/YPG.0000000000000061.
This is a case-control study of the association of NTNG1 subtypes with schizophrenia among a group of individuals from a Caucasian population. Netrins including NTNG1 are known to be axon guidance factors in the developing brain. They could be very important contributors to the genetic risk for psychosis. We examined the hypothesis that NTNG1 allelic variation contributes to the risk for schizophrenia. Our group was able to replicate the findings of Zhu and colleagues among Han Chinese individuals. This is the first finding of this association in a North American population.
这是一项病例对照研究，研究对象为一群高加索人群，旨在探究NTNG1亚型与精神分裂症之间的关联。已知包括NTNG1在内的Netrins是发育中大脑的轴突导向因子。它们可能是导致精神病遗传风险的重要因素。我们检验了NTNG1等位基因变异会增加精神分裂症风险这一假设。我们的研究小组能够在汉族人群中重复朱及其同事的研究结果。这是在北美人群中首次发现这种关联。
