免疫功能正常患者的巨细胞病毒性肝炎
Cytomegalovirus-induced hepatitis in an immunocompetent patient.
作者信息
Gupta Prashant, Suryadevara Madhu, Das Avash
机构信息
Department of Internal Medicine, Louisiana State University Health Sciences Center - University Hospital and Clinics, Lafayette, USA.
Department of Medicine, Nilratan Sircar Medical College, Kolkata, India.
出版信息
Am J Case Rep. 2014 Oct 18;15:447-9. doi: 10.12659/AJCR.890945.
BACKGROUND
Hepatitis is a descriptive term given for any inflammation of the liver. It can be characterized as inflammatory cells infiltrating normal hepatic parenchyma, which destroys their ability to perform normal physiologic functions. Hepatitis is a common disorder in immunocompetent populations, mainly attributed to viruses, alcohol, drugs, or autoimmune causes.
CASE REPORT
Cytomegalovirus is a virus mostly affecting immunocompromised patients, resulting in infectious mononucleosis-like symptoms as well as hepatitis in liver transplant patients, but is generally benign in immunocompetent hosts. This report presents an unusual case of hepatitis caused by Cytomegalovirus in an immunocompetent patient with previous Herpes Simplex virus infection. A 20-year-old African-American woman presenting with intermittent subjective fevers and chills, sore throat, non-productive cough, and decreased appetite 1 month ago was diagnosed with a case of Cytomegalovirus-induced hepatitis.
CONCLUSIONS
This report clearly emphasizes the need for investigation of other disease entities such as Cytomegalovirus as a potential cause of hepatitis in an immunocompetent patient after more common causes of hepatitis have been ruled out.
背景
肝炎是用于描述肝脏任何炎症的术语。其特征可为炎症细胞浸润正常肝实质，破坏其执行正常生理功能的能力。肝炎在免疫功能正常人群中是一种常见疾病，主要归因于病毒、酒精、药物或自身免疫性病因。
病例报告
巨细胞病毒是一种主要影响免疫功能低下患者的病毒，可导致肝移植患者出现传染性单核细胞增多症样症状以及肝炎，但在免疫功能正常宿主中通常为良性。本报告介绍了一例既往有单纯疱疹病毒感染的免疫功能正常患者发生巨细胞病毒所致肝炎的罕见病例。一名20岁非裔美国女性1个月前出现间歇性主观发热、寒战、咽痛、干咳和食欲减退，被诊断为巨细胞病毒诱导的肝炎。
结论
本报告明确强调，在排除更常见的肝炎病因后，对于免疫功能正常的肝炎患者，有必要调查其他疾病实体，如巨细胞病毒作为潜在病因。
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