Department of Internal Medicine, Bronx Care Health System, Bronx, NY, USA.
Department of Internal Medicine, Division of Infectious Disease, Bronx Care Health System, Bronx, NY, USA.
Am J Case Rep. 2020 Jul 16;21:e925495. doi: 10.12659/AJCR.925495.
BACKGROUND Cytomegalovirus (CMV) is a member of Herpesviridae family with its name derived from the fact that it causes enlargement of the infected cell resulting in the characteristic inclusion bodies seen on microscopy. CMV virus has an incubation period of about 4 to 6 weeks. Symptoms of CMV infection vary and depend on factors including the age and immune status of the patient. It usually presents as asymptomatic infection in immunocompetent individuals whereas severe disease is usually seen in immunocompromised patients. Here we present a case of an immunocompetent patient who presented with acute CMV hepatitis. CASE REPORT A 35-year-old male with no significant prior medical history who presented to the Emergency Department with a 2-week history of low-grade fever. Acute CMV infection was diagnosed by positive CMV antibody and polymerase chain reaction (PCR) testing. The patient was treated with valganciclovir that resulted in rapid improvement in clinical status as well as normalization of the liver enzymes. CONCLUSIONS This article presents a rare case of immunocompetent young male with acute CMV hepatitis who responded favorably to antiviral therapy.
巨细胞病毒（CMV）是疱疹病毒科的一员，其名称源于它导致受感染细胞增大，从而在显微镜下观察到特征性包涵体。CMV 病毒的潜伏期约为 4 至 6 周。CMV 感染的症状因患者的年龄和免疫状况等因素而异。它通常在免疫功能正常的个体中表现为无症状感染，而严重疾病通常见于免疫功能低下的患者。在这里，我们报告了一例免疫功能正常的患者，表现为急性 CMV 肝炎。
一名 35 岁男性，无明显既往病史，因持续两周的低热而到急诊科就诊。通过 CMV 抗体和聚合酶链反应（PCR）检测诊断为急性 CMV 感染。患者接受缬更昔洛韦治疗，临床状况迅速改善，肝酶恢复正常。
本文报告了一例罕见的免疫功能正常的年轻男性急性 CMV 肝炎病例，对抗病毒治疗反应良好。
