Kovacević Jadranka
Acta Med Croatica. 2014 Oct;68 Suppl 1:127-44.
Sclerotherapy is the targeted chemical ablation of varicose veins by intravenous injection of a liquid of foamed sclerosing drug. The treated veins may be intradermal, subcutaneous, and/or transfascial as well as superficial and deep in venous malformations. The aim of this guideline is to give evidence-based recommendations for liquid and foam sclerotherapy.
This guideline was drafted on behalf of 23 European Phlebological Societies during Guideline Conference on 7-10 May 2012 in Mainz. The conference was organized by the German Society of Phlebology. These guidelines review the present state of knowledge as reflected in published medical literature. The regulatory situation of sclerosant drugs differs from country to country but this has not been considered in this document. The recommendations of this guiedeline are graded according to the American College of Chest Physicians Task Force recommendations on Grading Strenght of Recommendations and Quality of Evidence in Clinical Guidelines.
This guideline focuses on the two sclerosing drugs which are licensed in the majority of the European countries, polidokanol and sodium tetradecyl sulphate. Other sclerosants are dot discussed in detail. The guideline gives recommendations concerning indications, contraindications, side-effects, concentrations, volumes, technique and efficacy of liquid and foam sclerotherapy of varicose veins and venous malformations.
硬化疗法是通过静脉注射液体或泡沫硬化剂药物对静脉曲张进行靶向化学消融。治疗的静脉可以是皮内、皮下和/或经筋膜的,也包括静脉畸形中的浅静脉和深静脉。本指南的目的是为液体和泡沫硬化疗法提供循证建议。
本指南由23个欧洲静脉病学会于2012年5月7日至10日在美因茨召开的指南会议期间起草。该会议由德国静脉病学会组织。这些指南回顾了已发表医学文献中反映的当前知识状态。硬化剂药物的监管情况因国家而异,但本文件未对此进行考虑。本指南的建议根据美国胸科医师学会临床指南中关于推荐强度分级和证据质量的工作组建议进行分级。
本指南重点关注在大多数欧洲国家获得许可的两种硬化剂药物,聚多卡醇和十四烷基硫酸钠。其他硬化剂未详细讨论。该指南给出了关于静脉曲张和静脉畸形的液体和泡沫硬化疗法的适应症、禁忌症、副作用、浓度、体积、技术和疗效的建议。