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接受高效抗逆转录病毒治疗（HAART）的骨和心血管功能受损的HIV阳性患者中的不变自然杀伤T（iNKT）细胞

Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.

作者信息

Tincati Camilla, Basilissi Matteo, Sinigaglia Elisabetta, Merlini Esther, Carpani Giovanni, Monforte Antonella d'Arminio, Marchetti Giulia

机构信息

Department of Health Sciences, Clinic of Infectious Diseases and Tropical Medicine, "San Paolo" Hospital, University of Milan, Milan, Italy.

Blood Transfusion Unit, "San Paolo" Hospital, Milan, Italy.

出版信息

PLoS One. 2014 Oct 17;9(10):e110287. doi: 10.1371/journal.pone.0110287. eCollection 2014.

DOI:10.1371/journal.pone.0110287
PMID:25329381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4201495/
Abstract

BACKGROUND

Invariant Natural Killer T (iNKT) cells represent a determinant in the course of infections and diseases, however, their role in the pathogenesis of non-infectious co-morbidities in HIV-positive patients is unknown.

METHODS

Flow cytometry was used to investigate iNKT cell frequency, phenotype and function in HIV-infected patients on HAART with bone and/or cardiovascular disorders and in HIV-positive controls free from co-morbidities.

RESULTS

iNKT cells from subjects with bone and cardiovascular impairment expressed high levels of CD161 and predominantly secreted TNF. iNKT cells from individuals with bone disease alone did not show any distinctive phenotypical or functional characteristics. The functional capacity of iNKT cells in patients with cardiovascular disorder was impaired with no cytokine release upon stimulation.

CONCLUSION

iNKT cells may have a role in non-infectious co-morbidities in treated HIV disease, possibly through the exacerbation of inflammation. Further studies are needed to investigate iNKT cells in the pathogenesis of non-communicable disorders in HIV infection.

摘要

背景

不变自然杀伤T（iNKT）细胞是感染和疾病进程中的一个决定因素，然而，它们在HIV阳性患者非感染性合并症发病机制中的作用尚不清楚。

方法

采用流式细胞术研究接受高效抗逆转录病毒治疗（HAART）且患有骨骼和/或心血管疾病的HIV感染患者以及无合并症的HIV阳性对照者体内iNKT细胞的频率、表型和功能。

结果

患有骨骼和心血管损伤的受试者的iNKT细胞表达高水平的CD161，且主要分泌肿瘤坏死因子（TNF）。仅患有骨骼疾病的个体的iNKT细胞未表现出任何独特的表型或功能特征。心血管疾病患者体内iNKT细胞的功能能力受损，刺激后无细胞因子释放。

结论

iNKT细胞可能在接受治疗的HIV疾病的非感染性合并症中起作用，可能是通过加剧炎症。需要进一步研究来调查iNKT细胞在HIV感染的非传染性疾病发病机制中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b80/4201495/9e3f11f32807/pone.0110287.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b80/4201495/de6533bec8a6/pone.0110287.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b80/4201495/9e3f11f32807/pone.0110287.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b80/4201495/de6533bec8a6/pone.0110287.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b80/4201495/9e3f11f32807/pone.0110287.g002.jpg

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