Di Mattei Valentina E, Carnelli Letizia, Ambrosi Alessandro, Mangili Giorgia, Candiani Massimo, Sarno Lucio
J Reprod Med. 2014 Sep-Oct;59(9-10):488-95.
To evaluate the impact of a forced delay in childbearing during thefollow-up period on the perceived fertility of patients with gestational trophoblastic disease (GTD), and to investigate how women react to the monitoring period, with particular attention to fertility concerns, personal perceptions of the impact of GTD on reproductive outcomes, and psychological symptoms of depression and anxiety.
Twenty women treated for GTD at San Raffaele Hospital, Milan, took part in the study. Depression, anxiety, and infertility-related stress were assessed using the Beck Depression Inventory-Short Form, the State-Trait Anxiety Inventory, and the Fertility Problem Inventory, respectively.
A significant difference in depression levels was found between women with hydatiform mole and women with gestational trophoblastic neoplasia (p = 0.02). On the contrary, anxiety and depression levels did not vary on the basis of time elapsed since diagnosis, presence of children, and age (< 35 years). A significant correlation was also found between anxiety (state and trait) and depression (rho(s) = 0.62, p = 0.002 and rho(s) = 0.59, p = 0.005. respectively). There was no association between infertility-related stress and anxiety or depression or time elapsed since diagnosis. Additionally, such stress did not change between women with or without children.
Women with GTD diagnosis should be followed by a multidisciplinary team so as to be supported in the disease's psychological aspects, too.
评估随访期间强制延迟生育对妊娠滋养细胞疾病（GTD）患者感知生育能力的影响，并调查女性对监测期的反应，尤其关注生育问题、个人对GTD对生殖结局影响的认知以及抑郁和焦虑的心理症状。
20名在米兰圣拉斐尔医院接受GTD治疗的女性参与了该研究。分别使用贝克抑郁量表简版、状态-特质焦虑量表和生育问题量表评估抑郁、焦虑和与不孕相关的压力。
葡萄胎女性和妊娠滋养细胞肿瘤女性之间的抑郁水平存在显著差异（p = 0.02）。相反，焦虑和抑郁水平并未因诊断后的时间、子女情况和年龄（< 35岁）而有所不同。焦虑（状态和特质）与抑郁之间也存在显著相关性（分别为rho(s) = 0.62，p = 0.002和rho(s) = 0.59，p = 0.005）。与不孕相关的压力与焦虑、抑郁或诊断后的时间无关。此外，有无子女的女性之间这种压力没有变化。
确诊为GTD的女性应由多学科团队进行随访，以便在疾病的心理方面也能得到支持。
