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住院期间急性肾损伤(AKI)发作后肾科门诊护理及AKI复发的预测因素。

Predictors for nephrology outpatient care and recurrence of acute kidney injury (AKI) after an in-hospital AKI episode.

作者信息

Xie Mingyang, Iqbal Sameena

机构信息

McGill University, Montreal, Quebec, Canada.

出版信息

Hemodial Int. 2014 Oct;18 Suppl 1:S7-12. doi: 10.1111/hdi.12217.

Abstract

Acute kidney injury (AKI) is associated with increased long-term risk of end-stage kidney disease (ESKD) and mortality. Nephrology care following discharge from hospital may improve survival through prevention of recurrent AKI events. In this study, we examined the factors that were associated with outpatient nephrology follow-up after the development of AKI on patients who had a nephrology in-hospital consultation and were discharged from McGill University Health Centre between January 1, 2006 and December 31, 2010. The associated factors for AKI-free survival postdischarge were assessed applying multivariate Cox hazard proportional models. Of 170 patients, only 22% of the AKI admissions studied were booked with nephrology follow-up after discharge. The unadjusted hazard ratio (HR) of outpatient nephrology care postdischarge was 1.82 (95% confidence interval [CI] 0.93-3.56) for AKI-free survival postdischarge. The adjusted HR was 2.04 (95% CI 1.01-4.12) when we adjusted for follow-up with other medical clinics, significant stage 4 and stage 5 chronic kidney disease and diabetes status. Patients with less comorbidities and higher serum creatinine on discharge received outpatient nephrology care. Nephrology outpatient care is associated with decreased risk of recurrence of AKI after discharge from hospital.

摘要

急性肾损伤(AKI)与终末期肾病(ESKD)和死亡率的长期风险增加相关。出院后的肾脏病护理可能通过预防AKI复发事件来提高生存率。在本研究中,我们调查了2006年1月1日至2010年12月31日期间在麦吉尔大学健康中心接受住院肾脏病会诊并出院的患者发生AKI后与门诊肾脏病随访相关的因素。应用多变量Cox风险比例模型评估出院后无AKI生存的相关因素。在170例患者中,所研究的AKI住院患者中只有22%在出院后安排了肾脏病随访。出院后门诊肾脏病护理对于出院后无AKI生存的未调整风险比(HR)为1.82(95%置信区间[CI] 0.93 - 3.56)。当我们对其他医疗诊所的随访、显著的4期和5期慢性肾脏病以及糖尿病状态进行调整后,调整后的HR为2.04(95% CI 1.01 - 4.12)。出院时合并症较少且血清肌酐较高的患者接受了门诊肾脏病护理。肾脏病门诊护理与出院后AKI复发风险降低相关。

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