Thomas Eric D, Cruz Ivan A, Hailey Dale W, Raible David W
Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA, USA; Department of Biological Structure, University of Washington, Seattle, WA, USA.
Wiley Interdiscip Rev Dev Biol. 2015 Jan-Feb;4(1):1-16. doi: 10.1002/wdev.160. Epub 2014 Oct 20.
The zebrafish lateral line is a sensory system used to detect changes in water flow. It is comprised of clusters of mechanosensory hair cells called neuromasts. The lateral line is initially established by a migratory group of cells, called a primordium, that deposits neuromasts at stereotyped locations along the surface of the fish. Wnt, FGF, and Notch signaling are all important regulators of various aspects of lateral line development, from primordium migration to hair cell specification. As zebrafish age, the organization of the lateral line becomes more complex in order to accommodate the fish's increased size. This expansion is regulated by many of the same factors involved in the initial development. Furthermore, unlike mammalian hair cells, lateral line hair cells have the capacity to regenerate after damage. New hair cells arise from the proliferation and differentiation of surrounding support cells, and the molecular and cellular pathways regulating this are beginning to be elucidated. All in all, the zebrafish lateral line has proven to be an excellent model in which to study a diverse array of processes, including collective cell migration, cell polarity, cell fate, and regeneration.
斑马鱼的侧线是一种用于检测水流变化的感觉系统。它由称为神经丘的机械感觉毛细胞簇组成。侧线最初由一群迁移的细胞（称为原基）建立，这些原基在鱼体表的固定位置沉积神经丘。Wnt、FGF和Notch信号通路都是侧线发育各个方面的重要调节因子，从原基迁移到毛细胞特化。随着斑马鱼年龄的增长，侧线的组织结构变得更加复杂，以适应鱼体的生长。这种扩展由许多与初始发育相同的因素调节。此外，与哺乳动物的毛细胞不同，侧线毛细胞在受损后具有再生能力。新的毛细胞由周围支持细胞的增殖和分化产生，调节这一过程的分子和细胞途径正开始被阐明。总而言之，斑马鱼侧线已被证明是研究包括集体细胞迁移、细胞极性、细胞命运和再生等多种过程的优秀模型。
