The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Dev Neurobiol. 2012 Mar;72(3):234-55. doi: 10.1002/dneu.20962.
The posterior lateral line (pLL) in zebrafish has emerged as an excellent system to study how a sensory organ system develops. Here we review recent studies that illustrate how interactions between multiple signaling pathways coordinate cell fate,morphogenesis, and collective migration of cells in the posterior lateral line primordium. These studies also illustrate how the pLL system is contributing much more broadly to our understanding of mechanisms operating during the growth, regeneration, and self-organization of other organ systems during development and disease.
斑马鱼的后侧线系统（pLL）已成为研究感觉器官系统发育的绝佳系统。本文综述了最近的研究，这些研究阐明了多种信号通路之间的相互作用如何协调后侧线原基中细胞命运、形态发生和细胞集体迁移。这些研究还阐明了 pLL 系统如何更广泛地促进我们对发育和疾病过程中其他器官系统的生长、再生和自我组织过程中作用机制的理解。
