从哪里开始呢？在全基因组范围内绘制大肠杆菌中的转录起始位点。
Where to begin? Mapping transcription start sites genome-wide in Escherichia coli.
作者信息
Wade Joseph T
机构信息
Wadsworth Center, New York State Department of Health, Albany, New York, USA Department of Biomedical Sciences, University at Albany, Albany, New York, USA
出版信息
J Bacteriol. 2015 Jan 1;197(1):4-6. doi: 10.1128/JB.02410-14. Epub 2014 Oct 20.
Abstract
Recent genome-wide studies of bacterial transcription have revealed large numbers of promoters located inside genes. In this issue of the Journal of Bacteriology, Thomason and colleagues (J. Bacteriol. 197:18-28, 2015, doi:10.1128/JB.02096-14) map transcription start sites in Escherichia coli on an unprecedented scale. This work provides important insights into the regulation of transcripts that initiate inside genes and sources of variability between studies aimed at identifying these RNAs.
摘要
近期对细菌转录的全基因组研究发现了大量位于基因内部的启动子。在本期《细菌学杂志》中，托马森及其同事（《细菌学杂志》197:18 - 28, 2015, doi:10.1128/JB.02096 - 14）以前所未有的规模绘制了大肠杆菌中的转录起始位点。这项工作为基因内部起始的转录本调控以及旨在鉴定这些RNA的研究之间的变异性来源提供了重要见解。
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