Ormerod A D, Wakeel R A, Mann T A, Main R A, Aldridge R D
Dermatology Department, Aberdeen Royal Infirmary, Foresterhill, UK.
Contact Dermatitis. 1989 Nov;21(5):326-9. doi: 10.1111/j.1600-0536.1989.tb04752.x.
Oil-based mud, a complex mixture containing amines in emulsifiers, is used in offshore drilling operations. It is a skin irritant that occasionally gives rise to allergic contact sensitivity. In patch testing patients with allergy to drilling mud, we have identified polyamine (diethylenetriamine and triethylenetetramine) sensitivity in 5 patients. All 5 patients were also allergic to emulsifiers. These emulsifiers are cross-linked fatty acid amido-amines, in which unreacted amine groups are thought to cross-sensitize with these constituent polyamines. Cross-reactivity between ethylenediamine, diethylenetetramine and triethylenetetramine was found in 9 subjects.
油基泥浆是一种在海上钻井作业中使用的复杂混合物，其乳化剂中含有胺类物质。它是一种皮肤刺激物，偶尔会引起过敏性接触敏感性。在对钻井泥浆过敏的患者进行斑贴试验时，我们在5名患者中发现了多胺（二乙烯三胺和三乙烯四胺）敏感性。所有5名患者也对乳化剂过敏。这些乳化剂是交联脂肪酸酰胺胺，其中未反应的胺基被认为会与这些多胺成分发生交叉致敏。在9名受试者中发现乙二胺、二乙烯四胺和三乙烯四胺之间存在交叉反应。
