Kermani Mahdi Sharifzadeh, Karimi Mina Haj-Mohammad, Sharifi Ali, Shadravan Mahla, Daneshtalab Arash, Zand Amin
Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
J Ophthalmic Vis Res. 2025 May 19;20. doi: 10.18502/jovr.v20.15048. eCollection 2025.
To assess the effects of phacoemulsification, visco-synechiolysis, and trabeculectomy on eyes with a recent history of acute primary angle closure (APAC).
In this prospective nonrandomized study, we enrolled patients with cataracts, peripheral anterior synechiae (PAS), and a history of APAC attack managed with medications and laser peripheral iridotomy (LPI) within the past six weeks. Patients without signs of glaucomatous optic neuropathy (GON) underwent phacoemulsification and visco-synechiolysis (PV group). Trabeculectomy was added to this procedure for cases with signs of underlying chronic GON (PVT group). We evaluated best-corrected visual acuity (BCVA), intraocular pressure (IOP), angle opening, PAS extension, and adverse events at baseline and six months postoperatively.
The PV and PVT groups comprised 8 and 12 eyes, respectively. At month six, both groups showed significant improvement in BCVA, reduced IOP, and increased Shaffer grading scores compared to baseline (all s 0.05). Extensive PAS ( 180º) significantly decreased at month six in both the PV ( = 0.008) and PVT ( = 0.002) groups compared to baseline. However, its prevalence did not significantly differ between the two groups at baseline ( = 0.288) or six months after surgery ( = 0.881). At month six, IOP was significantly lower in the PVT group than the PV group (10.83 1.40 vs 13.63 2.07 mmHg, = 0.002). Nevertheless, BCVA and Shaffer grading scores were not different between the two groups at this time point ( = 0.120, and = 0.891, respectively). No serious complications were observed in any groups during the follow-ups.
Patients with cataracts and a recent history of APAC without underlying chronic glaucoma may not receive additional trabeculectomy alongside lens extraction and synechiolysis.
评估超声乳化白内障吸除术、粘连分离术和小梁切除术对近期有急性原发性闭角型青光眼(APAC)发作史的眼睛的影响。
在这项前瞻性非随机研究中,我们纳入了患有白内障、周边前粘连(PAS)且在过去六周内接受过药物治疗和激光周边虹膜切开术(LPI)的APAC发作史患者。无青光眼性视神经病变(GON)体征的患者接受超声乳化白内障吸除术和粘连分离术(PV组)。对于有潜在慢性GON体征的病例,在此手术基础上加做小梁切除术(PVT组)。我们在基线和术后六个月评估最佳矫正视力(BCVA)、眼压(IOP)、房角开放、PAS范围及不良事件。
PV组和PVT组分别有8只眼和12只眼。在术后六个月时,与基线相比,两组的BCVA均显著改善、眼压降低且Shaffer分级评分增加(所有P<0.05)。与基线相比,PV组(P = 0.008)和PVT组(P = 0.002)在术后六个月时广泛PAS(≥180°)均显著减少。然而,两组在基线时(P = 0.288)或术后六个月时(P = 0.881)其患病率无显著差异。在术后六个月时,PVT组的眼压显著低于PV组(10.83±1.40 vs 13.63±2.07 mmHg,P = 0.002)。然而,此时两组的BCVA和Shaffer分级评分无差异(分别为P = 0.120和P = 0.891)。随访期间,任何组均未观察到严重并发症。
近期有APAC发作史且无潜在慢性青光眼的白内障患者,在进行晶状体摘除和粘连分离术时可能无需额外进行小梁切除术。