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急性原发性闭角型青光眼初始治疗后行白内障超声乳化吸除联合粘连松解术(伴或不伴小梁切除术)的对比研究

Phacoemulsification and Visco-synechiolysis With or Without Trabeculectomy Following Initial Management of Acute Primary Angle Closure: A Comparative Study.

作者信息

Kermani Mahdi Sharifzadeh, Karimi Mina Haj-Mohammad, Sharifi Ali, Shadravan Mahla, Daneshtalab Arash, Zand Amin

机构信息

Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

J Ophthalmic Vis Res. 2025 May 19;20. doi: 10.18502/jovr.v20.15048. eCollection 2025.

Abstract

PURPOSE

To assess the effects of phacoemulsification, visco-synechiolysis, and trabeculectomy on eyes with a recent history of acute primary angle closure (APAC).

METHODS

In this prospective nonrandomized study, we enrolled patients with cataracts, peripheral anterior synechiae (PAS), and a history of APAC attack managed with medications and laser peripheral iridotomy (LPI) within the past six weeks. Patients without signs of glaucomatous optic neuropathy (GON) underwent phacoemulsification and visco-synechiolysis (PV group). Trabeculectomy was added to this procedure for cases with signs of underlying chronic GON (PVT group). We evaluated best-corrected visual acuity (BCVA), intraocular pressure (IOP), angle opening, PAS extension, and adverse events at baseline and six months postoperatively.

RESULTS

The PV and PVT groups comprised 8 and 12 eyes, respectively. At month six, both groups showed significant improvement in BCVA, reduced IOP, and increased Shaffer grading scores compared to baseline (all s 0.05). Extensive PAS ( 180º) significantly decreased at month six in both the PV ( = 0.008) and PVT ( = 0.002) groups compared to baseline. However, its prevalence did not significantly differ between the two groups at baseline ( = 0.288) or six months after surgery ( = 0.881). At month six, IOP was significantly lower in the PVT group than the PV group (10.83 1.40 vs 13.63 2.07 mmHg, = 0.002). Nevertheless, BCVA and Shaffer grading scores were not different between the two groups at this time point ( = 0.120, and = 0.891, respectively). No serious complications were observed in any groups during the follow-ups.

CONCLUSION

Patients with cataracts and a recent history of APAC without underlying chronic glaucoma may not receive additional trabeculectomy alongside lens extraction and synechiolysis.

摘要

目的

评估超声乳化白内障吸除术、粘连分离术和小梁切除术对近期有急性原发性闭角型青光眼(APAC)发作史的眼睛的影响。

方法

在这项前瞻性非随机研究中,我们纳入了患有白内障、周边前粘连(PAS)且在过去六周内接受过药物治疗和激光周边虹膜切开术(LPI)的APAC发作史患者。无青光眼性视神经病变(GON)体征的患者接受超声乳化白内障吸除术和粘连分离术(PV组)。对于有潜在慢性GON体征的病例,在此手术基础上加做小梁切除术(PVT组)。我们在基线和术后六个月评估最佳矫正视力(BCVA)、眼压(IOP)、房角开放、PAS范围及不良事件。

结果

PV组和PVT组分别有8只眼和12只眼。在术后六个月时,与基线相比,两组的BCVA均显著改善、眼压降低且Shaffer分级评分增加(所有P<0.05)。与基线相比,PV组(P = 0.008)和PVT组(P = 0.002)在术后六个月时广泛PAS(≥180°)均显著减少。然而,两组在基线时(P = 0.288)或术后六个月时(P = 0.881)其患病率无显著差异。在术后六个月时,PVT组的眼压显著低于PV组(10.83±1.40 vs 13.63±2.07 mmHg,P = 0.002)。然而,此时两组的BCVA和Shaffer分级评分无差异(分别为P = 0.120和P = 0.891)。随访期间,任何组均未观察到严重并发症。

结论

近期有APAC发作史且无潜在慢性青光眼的白内障患者,在进行晶状体摘除和粘连分离术时可能无需额外进行小梁切除术。

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本文引用的文献

3
Early phacoemulsification in patients with acute primary angle closure.急性原发性闭角型青光眼患者的早期超声乳化术
J Curr Ophthalmol. 2016 Jan 12;27(3-4):70-5. doi: 10.1016/j.joco.2015.12.001. eCollection 2015 Sep-Dec.
10
Role of phacoemulsification in angle closure glaucoma.超声乳化术在闭角型青光眼中的作用。
Eye Sci. 2011 Sep;26(3):121-31. doi: 10.3969/j.issn.1000-4432.2011.03.001.

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