Arenaz P, Bitticks L, Pannell K, Garcia S
Department of Biological Sciences, University of Texas El Paso 79968.
Mutagenesis. 1989 Nov;4(6):437-8. doi: 10.1093/mutage/4.6.437.
Macrocyclic polyethers (crown ethers) are a family of compounds which possess the ability to transport ionic species across natural and artificial membranes. Because of this characteristic, they have wide applications in industry and are being investigated for their potential as pharmacologic agents. However, these compounds are highly cytotoxic in both prokaryotes and eukaryotes. Because of the cytotoxicity of crown ethers, an investigation of the potential genotoxicity of these compounds in Salmonella typhimurium was initiated. Several unsubstituted and substituted crown ethers did not induce a genotoxic response in S. typhimurium strains TA100, TA1530, TA98 and TA1537 either with or without rat liver S9 mixture. The data support the conclusion that the toxicity of these compounds is probably not due to an interaction with nucleic acid to induce premutagenic lesions and they do not appear to be genotoxic in prokaryotes.
大环聚醚（冠醚）是一类能够携带离子穿过天然和人工膜的化合物。由于这一特性，它们在工业上有广泛应用，并且因其作为药物的潜力而受到研究。然而，这些化合物在原核生物和真核生物中都具有高度细胞毒性。由于冠醚的细胞毒性，因此开展了对这些化合物在鼠伤寒沙门氏菌中潜在遗传毒性的研究。几种未取代和取代的冠醚在有或没有大鼠肝脏S9混合物的情况下，都未在鼠伤寒沙门氏菌TA100、TA1530、TA98和TA1537菌株中诱导遗传毒性反应。这些数据支持以下结论：这些化合物的毒性可能不是由于与核酸相互作用诱导前诱变损伤所致，并且它们在原核生物中似乎没有遗传毒性。
