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副肿瘤性红细胞增多症继发短暂性脑缺血发作。

Transient ischaemic attack secondary to paraneoplastic erythrocytosis.

作者信息

Hurtarte Sandoval Aldo René, Flores Robles Bryan Josué, Andrus Robert Francis, Yaxcal Chon David Alejandro

机构信息

Department of Internal Medicine, San Juan de Dios General Hospital, Guatemala, Guatemala.

Department of Rheumatology, Puerta de Hierro Majada Honda Hospital, Madrid, Spain.

出版信息

BMJ Case Rep. 2014 Oct 21;2014:bcr2013202572. doi: 10.1136/bcr-2013-202572.

DOI:10.1136/bcr-2013-202572
PMID:25336545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4208132/
Abstract

A 67-year-old woman with a history of hypertension and type 2 diabetes mellitus was admitted to the hospital due to aphasia and left-sided hemiparesis during the past 5 h with resolution of symptoms within 24 h. On admission laboratory analysis showed haemoglobin 19.2 g/dL and haematocrit 55.1%. Cerebral CT scan was also performed on admission revealing periventricular leucoaraiosis. Studies to investigate the cause of erythrocytosis were started and elevated erythropoietin levels were found. In order to investigate a secondary cause of erythrocytosis an abdominal ultrasound was conducted revealing a left renal mass. CT scans of thorax, abdomen and pelvis confirmed renal mass 8 × 8 cm of diameter, suggestive of neoplasm without associated lymphadenopathy or metastases. Radical nephrectomy was performed and a pathological diagnosis demonstrated clear cell renal cell carcinoma and was staged as T2aN0M0.

摘要

一名67岁女性,有高血压和2型糖尿病病史,因在过去5小时内出现失语和左侧偏瘫入院,症状在24小时内缓解。入院时实验室分析显示血红蛋白19.2g/dL,血细胞比容55.1%。入院时还进行了脑部CT扫描,显示脑室周围白质疏松症。开始进行研究以调查红细胞增多症的病因,发现促红细胞生成素水平升高。为了调查红细胞增多症的继发原因,进行了腹部超声检查,发现左肾有肿块。胸部、腹部和骨盆的CT扫描证实肾肿块直径为8×8cm,提示为肿瘤,无相关淋巴结病或转移。进行了根治性肾切除术,病理诊断为透明细胞肾细胞癌,分期为T2aN0M0。

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Ischemic Stroke Caused by Secondary Polycythemia and Incidentally-Found Renal Cell Carcinoma: A Case Report.继发性红细胞增多症及偶然发现的肾细胞癌所致缺血性脑卒中:一例报告
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von Hippel-Lindau disease: a clinical and scientific review.血管母细胞瘤病:临床与科学综述。
Eur J Hum Genet. 2011 Jun;19(6):617-23. doi: 10.1038/ejhg.2010.175. Epub 2011 Mar 9.
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Chromosomal abnormalities of clear cell renal cell carcinoma: frequent gain of chromosome 7.透明细胞肾细胞癌的染色体异常:7 号染色体常增益。
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Thrombocytosis is associated with a significant increase in the cancer specific death rate after radical nephrectomy.血小板增多症与根治性肾切除术后癌症特异性死亡率的显著增加相关。
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Paraneoplastic manifestations of renal cell carcinoma.肾细胞癌的副肿瘤表现
Semin Urol Oncol. 1996 Nov;14(4):216-22.