在一名冠心病患者中安全有效地使用慢性经皮雌二醇治疗危及生命的尿毒症出血。
Safe and effective use of chronic transdermal estradiol for life-threatening uremic bleeding in a patient with coronary artery disease.
作者信息
Bali Atul, Hix John Kevin, Kouides Peter
机构信息
Department of Internal Medicine, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, N.Y., USA.
Department of Internal Medicine, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, N.Y., USA ; Nephrology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, N.Y., USA.
出版信息
Nephron Extra. 2014 Aug 19;4(2):134-7. doi: 10.1159/000365480. eCollection 2014 May.
Uremic platelet dysfunction rarely causes significant bleeding in adequately dialyzed patients. When encountered, the management is complicated by a lack of well-supported treatment modalities. Estrogen use in uremic platelet dysfunction has been described, but enthusiasm for the treatment has been dampened by the risk of thrombotic events in vasculopathic dialysis patients. We present a patient on long-term peritoneal dialysis with coronary disease who developed recurrent life-threatening bleeding episodes secondary to uremia, where treatment with transdermal estrogen was used safely and effectively for a 24-month period.
尿毒症血小板功能障碍在透析充分的患者中很少导致严重出血。一旦出现这种情况，由于缺乏有力的治疗方式，管理起来会很复杂。已有文献报道在尿毒症血小板功能障碍中使用雌激素，但血管病变透析患者发生血栓事件的风险降低了人们对这种治疗方法的热情。我们报告了一名长期接受腹膜透析且患有冠心病的患者，该患者因尿毒症出现反复危及生命的出血发作，经皮雌激素治疗在此患者中安全有效地使用了24个月。
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