Aydin Ozlem Altuntas, Yemisen Mucahit, Karaosmanoglu Hayat Kumbasar, Sargin Fatma, Gunduz Alper, Ceylan Bahadir, Mete Bilgul, Ozgunes Nail, Sevgi Dilek Yildiz, Ozaras Resat, Tabak Fehmi
Department of Infectious Diseases and Clinical Microbiology, Haseki Training and Research Hospital, Istanbul, Turkey.
Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Hepat Mon. 2014 Aug 16;14(8):e18128. doi: 10.5812/hepatmon.18128. eCollection 2014 Aug.
Rate of coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) varies in different countries. This may be attributable to common transmission routes as well as social, economic, and cultural factors.
The purpose of this study was to investigate the prevalence and risk factors of HCV infection among HIV-positive patients in Istanbul, Turkey.
Since January 2006 to November 2013, 949 HIV-positive patients that were enrolled in this study by ACTHIV-IST (Action Against HIV in Istanbul) Study Group, which consists of five centers to follow up HIV-positive patients in Istanbul. Epidemiologic and clinical data were collected retrospectively from medical records and were transferred to an HIV database system.
Among 949 patients, 84% were men and the mean age was 37.92 ± 11.54 years (range, 17-79). The most frequent route of transmission was heterosexual intercourse (48.8%), followed by men having sex with men (30.5%). Only nine patients (0.9%) had history of injection drug use (IDU). The prevalence of HIV/HCV coinfection was 0.9% (9:949). The IDU rate was 44.4% (4:9) in patients with HIV/HCV coinfection (three of them were not Turkish citizens), whereas this rate was only 0.6% (5:881) in patients with only HIV infection (P < 0.01). Genotypes 1b, 2a/2c, and 3 were determined in five, one, and two patients, respectively. Genotype could not be determined in one patient. History of residence in a foreign country (P < 0.01) and imprisonment (P < 0.01) were also considered as risk factors in terms of HIV/HCV coinfection.
Prevalence of HIV/HCV coinfection is considerably low in Turkey. The extremely rare prevalence of IDU might have a role in this low prevalence.
人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）合并感染率在不同国家有所不同。这可能归因于共同的传播途径以及社会、经济和文化因素。
本研究旨在调查土耳其伊斯坦布尔HIV阳性患者中HCV感染的患病率及危险因素。
自2006年1月至2013年11月，949例HIV阳性患者由伊斯坦布尔抗HIV行动（ACTHIV-IST）研究组纳入本研究，该研究组由五个中心组成，负责随访伊斯坦布尔的HIV阳性患者。流行病学和临床数据从病历中回顾性收集，并转入HIV数据库系统。
949例患者中，84%为男性，平均年龄为37.92±11.54岁（范围17 - 79岁）。最常见的传播途径是异性性行为（48.8%），其次是男男性行为（30.5%）。只有9例患者（0.9%）有注射吸毒史（IDU）。HIV/HCV合并感染率为0.9%（9/949）。HIV/HCV合并感染患者的IDU率为44.4%（4/9）（其中3例不是土耳其公民），而仅HIV感染患者的这一比例仅为0.6%（5/881）（P<0.01）。分别在5例、1例和2例患者中检测到1b型、2a/2c型和3型基因型。1例患者无法确定基因型。在国外居住史（P<0.01）和监禁史（P<0.01）在HIV/HCV合并感染方面也被视为危险因素。
土耳其HIV/HCV合并感染率相当低。IDU的极低患病率可能在这种低患病率中起作用。
