[人类免疫缺陷病毒感染患者中丙型肝炎病毒合并感染的患病率及基因型分布变化]
[Prevalence and genotype distribution changes in hepatitis C virus co-infection among human immunodeficiency virus-infected patients].
作者信息
Cifuentes Celia, Mancebo-Hernández María, Pérez-Navarro Elisabet, Recio Eva, Monje-Agudo Patricia, Valiente Adoración, Pineda Juan A
机构信息
Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, España.
Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, España; Unidad Clínica Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Macarena, Sevilla, España.
出版信息
Enferm Infecc Microbiol Clin. 2015 Feb;33(2):110-2. doi: 10.1016/j.eimc.2014.05.010. Epub 2014 Dec 12.
BACKGROUND
The prevalence of hepatitisC is decreasing among new diagnoses of HIV/HCV coinfection in Spain. The increasing use of the HCV treatment could have changed the HCV genotype distribution. The aim of this study is to analyze changes in the prevalence of HCV coinfection and in HCV genotype distribution among HIV-infected patients.
METHODS
A serial cross-sectional study was conducted that included all HIV-infected patients who attended the Outpatient Clinic of a hospital in Andalusia, between September 2008 and February 2009 (first period), and between January 2013 and June 2013 (second period).
RESULTS
A total of 520 and 651 patients were included in the first and second period, respectively. The risk factors of HCV infection in the first vs. second period were: IDU, 319 (61%) vs. 348 (53%); heterosexual contact, 111 (21%) vs. 135 (21%); homosexual men, 76 (15%) vs. 114 (22%) (P=.006). The prevalence of HCV antibody per period was: 358 (69%) vs. 380 (58%) (P=<.001), and for the HCV-RNA was 255 (49%) vs. 240 (37%) (P=<.001). In both periods, the HCV genotype distribution was: 1, 137 (60%) vs. 138 (59%); 3, 45 (20%) vs. 42 (18%); 4, 42 (18%) vs. 47 (20%) (P=.881).
CONCLUSIONS
The prevalence of HCV infection in HIV-infected patients has decreased in our area, including overall exposure to HCV virus and active infection during the last 5 years. However, the HCV genotype distribution has not changed.
背景
在西班牙，新诊断出的HIV/HCV合并感染患者中丙型肝炎的患病率正在下降。丙型肝炎病毒（HCV）治疗的使用增加可能改变了HCV基因型分布。本研究的目的是分析HIV感染患者中HCV合并感染患病率及HCV基因型分布的变化。
方法
进行了一项系列横断面研究，纳入了2008年9月至2009年2月（第一阶段）以及2013年1月至2013年6月（第二阶段）期间在安达卢西亚一家医院门诊就诊的所有HIV感染患者。
结果
第一阶段和第二阶段分别纳入了520例和651例患者。第一阶段与第二阶段HCV感染的危险因素如下：注射吸毒（IDU），分别为319例（61%）和348例（53%）；异性接触，分别为111例（21%）和135例（21%）；男同性恋者，分别为76例（15%）和114例（22%）（P = 0.006）。各阶段HCV抗体的患病率分别为：358例（69%）和380例（58%）（P < 0.001），HCV-RNA的患病率分别为255例（49%）和240例（37%）（P < 0.001）。在两个阶段中，HCV基因型分布情况为：1型，分别为137例（60%）和138例（59%）；3型，分别为45例（20%）和42例（18%）；4型，分别为42例（l8%）和47例（20%）（P = 0.881）。
结论
在我们地区，HIV感染患者中HCV感染的患病率有所下降，包括过去5年中HCV病毒的总体暴露率和活动性感染率。然而，HCV基因型分布并未改变。
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