The Children's Hospital of Philadelphia, Division of Neurology, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, Pennsylvania 19104-4399, USA.
Nat Rev Neurosci. 2013 May;14(5):337-49. doi: 10.1038/nrn3482. Epub 2013 Apr 18.
Epilepsy is a prevalent neurological disorder associated with significant morbidity and mortality, but the only available drug therapies target its symptoms rather than the underlying cause. The process that links brain injury or other predisposing factors to the subsequent emergence of epilepsy is termed epileptogenesis. Substantial research has focused on elucidating the mechanisms of epileptogenesis so as to identify more specific targets for intervention, with the hope of preventing epilepsy before seizures emerge. Recent work has yielded important conceptual advances in this field. We suggest that such insights into the mechanisms of epileptogenesis converge at the level of cortical circuit dysfunction.
癫痫是一种常见的神经障碍，与显著的发病率和死亡率相关，但唯一可用的药物治疗方法针对的是其症状，而不是根本原因。将脑损伤或其他易患因素与随后出现的癫痫联系起来的过程称为癫痫发生。大量研究集中在阐明癫痫发生的机制，以便为干预确定更具体的目标，希望在癫痫发作出现之前预防癫痫。最近的工作在这一领域取得了重要的概念进展。我们认为，对癫痫发生机制的这些认识在皮质电路功能障碍的层面上汇聚。
