Sofiabadi Mohammad, Azhdari-Zarmehri Hassan, Naderi Firouzeh, Ghalandari-Shamami Mohadeseh, Sonboli Ali, Haghparast Abbas
Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Basic Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Basic Clin Neurosci. 2014 Spring;5(2):162-8.
Tanacetum sonbolii (Asteraceae) is an endemic species in Iran. In the present study, we examined the effects of Tanacetum sonbolii hydroalcoholic extract on the formalin test in mice.
126 Swiss albino mice weighing 230-280g were used as subjects. The formalin test was performed on two control groups (marked as intact and saline groups; n = 6 in each group) and an experimental group. In all groups, the formalin test was recorded for 60 min after administration of extract and drugs in mice.
The results showed that Tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. In addition, different doses of Tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. On the other hand, morphine could induce antinociception in a dose-dependent manner. Diclofenac (10 mg/kg) failed to affect the pain scores compared to Tanacetum sonbolii (300 mg/kg) group.
It seems that administration of hydroalcoholic extract of Tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception.
桑博勒菊蒿（菊科）是伊朗的特有物种。在本研究中，我们研究了桑博勒菊蒿水醇提取物对小鼠福尔马林试验的影响。
将126只体重230 - 280克的瑞士白化小鼠作为实验对象。对两个对照组（标记为完整组和生理盐水组；每组n = 6）和一个实验组进行福尔马林试验。在所有组中，给小鼠给药提取物和药物后，记录60分钟的福尔马林试验情况。
结果表明，桑博勒菊蒿（150和300毫克/千克）在第2阶段产生了显著的镇痛作用。此外，不同剂量的桑博勒菊蒿提取物（600、900和1200毫克/千克）在第1阶段和第2阶段也诱导了镇痛作用。另一方面，吗啡能以剂量依赖的方式诱导镇痛作用。与桑博勒菊蒿（300毫克/千克）组相比，双氯芬酸（10毫克/千克）未能影响疼痛评分。
似乎给予桑博勒菊蒿水醇提取物有可能通过中枢和外周机制缓解持续性炎性伤害感受中的疼痛。
