Prout G R, Lin C W, Benson R, Nseyo U O, Daly J J, Griffin P P, Kinsey J, Tian M E, Lao Y H, Mian Y Z
Urology Service, Massachusetts General Hospital, Boston 02114.
N Engl J Med. 1987 Nov 12;317(20):1251-5. doi: 10.1056/NEJM198711123172003.
Photodynamic therapy involves light-induced destruction of tumors containing a photosensitizer such as hematoporphyrin derivative. We conducted a collaborative study to evaluate the efficacy of this form of therapy in treating superficial transitional-cell carcinoma of the bladder. Thirty-seven patients were evaluated and 20 were selected for treatment. A total of 50 papillary tumors and 3 areas of carcinoma in situ were treated. All except two tumors were smaller than 2.5 cm. Assessments for treatment response and toxicity were carried out three months after treatment. The initial diagnosis of one patient was revised after the biopsy material was reviewed, and this patient was not included in the analysis. Complete eradication of all tumors was observed in 9 of 19 patients (47 percent), including those with carcinoma in situ. In the remaining 10 of these 19 patients, 13 tumors could not be eradicated (the overall eradication rate was 37 of 50 tumors [74 percent]), but 9 of the 10 patients had a reduction in tumor size, number, or both of 50 percent or more. We conclude that photodynamic therapy is useful in the treatment of superficial transitional-cell carcinoma of the bladder, but controlled trials will be required to define its place in the treatment of cancer.
光动力疗法是利用光诱导破坏含有诸如血卟啉衍生物等光敏剂的肿瘤。我们开展了一项合作研究，以评估这种治疗方式在治疗膀胱浅表移行细胞癌中的疗效。对37例患者进行了评估，选择了20例进行治疗。共治疗了50个乳头状肿瘤和3个原位癌区域。除两个肿瘤外，所有肿瘤均小于2.5厘米。在治疗三个月后对治疗反应和毒性进行评估。一名患者的活检材料经复查后修正了初步诊断，该患者未纳入分析。在19例患者中的9例（47%）观察到所有肿瘤完全根除，包括原位癌患者。在这19例患者中的其余10例中，13个肿瘤未能根除（总体根除率为50个肿瘤中的37个[74%]），但10例患者中有9例肿瘤大小、数量或两者减少了50%或更多。我们得出结论，光动力疗法在治疗膀胱浅表移行细胞癌中是有用的，但需要进行对照试验来确定其在癌症治疗中的地位。
