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[胃肠道肿瘤的光化学疗法——50例血卟啉衍生物(HpD)加激光光动力疗法分析]

[Photo-chemistry therapy of gastrointestinal tumor--analysis of hematoporphyrin derivative (HpD) plus laser photodynamic therapy of 50 cases].

作者信息

Jin M L

出版信息

Zhonghua Zhong Liu Za Zhi. 1986 Jan;8(1):64-6.

PMID:3732027
Abstract

This paper reports 50 cases of gastrointestinal tumors treated by photodynamic therapy. The dose of HpD was 5 mg/kg. Fourty-eight to 72 hours after HpD injection, laser (wavelength 630 nm, power density 100-250 J/cm2), transmitted through a quartz fiber, was given. The criteria of therapeutic effectiveness were: complete remission (CR), significant remission (SR), minor remission (MR) and no remission (NR). All patients received endoscopic examination 4 weeks after treatment. No severe complication was observed. Thirty-eight of 50 cases gave CR, SR or MR (76%). The factors effecting treatment are discussed.

摘要

本文报道了50例接受光动力疗法治疗的胃肠道肿瘤患者。血卟啉衍生物(HpD)的剂量为5毫克/千克。注射HpD后48至72小时,通过石英纤维传输的激光(波长630纳米,功率密度100 - 250焦/平方厘米)进行照射。治疗效果标准为:完全缓解(CR)、显著缓解(SR)、轻度缓解(MR)和无缓解(NR)。所有患者在治疗后4周接受内镜检查。未观察到严重并发症。50例患者中有38例达到CR、SR或MR(76%)。文中讨论了影响治疗的因素。

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