Athirajan Vimmitra, Razak Ishak Abdul, Thurairajah Nalina, Ghani Wan Maria Nabillah, Ching Helen-Ng Lee, Yang Yi-Hsin, Peng Karen-Ng Lee, Abdul Rahman Zainal Ariff, Mustafa Wan Mahadzir Wan, Abraham Mannil Thomas, Kiong Tay Keng, Mun Yuen Kar, Jalil Norma, Zain Rosnah Binti
Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University Malaya, Kuala Lumpur, Malaysia E-mail :
Asian Pac J Cancer Prev. 2014;15(19):8183-9. doi: 10.7314/apjcp.2014.15.19.8183.
A comparative cross-sectional study involving oral cancer patients and healthy individuals was designed to investigate associations between retinol, α-tocopherol and β-carotene with the risk of oral cancer.
This study included a total of 240 matched cases and controls where subjects were selected from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). Retinol, α-tocopherol and β-carotene levels and intake were examined by high-performance liquid chromatography (HPLC) and food frequency questionnaire (FFQ) respectively.
It was found that results from the two methods applied did not correlate, so that further analysis was done using the HPLC method utilising blood serum. Serum levels of retinol and α-tocopherol among cases (0.177±0.081, 1.649±1.670μg/ml) were significantly lower than in controls (0.264±0.137, 3.225±2.054μg/ml) (p<0.005). Although serum level of β-carotene among cases (0.106±0.159 μg/ml) were lower compared to controls (0.134±0.131μg/ml), statistical significance was not observed. Logistic regression analysis showed that high serum level of retinol (OR=0.501, 95% CI=0.254-0.992, p<0.05) and α-tocopherol (OR=0.184, 95% CI=0.091-0.370, p<0.05) was significantly related to lower risk of oral cancer, whereas no relationship was observed between β-carotene and oral cancer risk.
High serum levels of retinol and α-tocopherol confer protection against oral cancer risk.
设计了一项涉及口腔癌患者和健康个体的比较横断面研究，以调查视黄醇、α-生育酚和β-胡萝卜素与口腔癌风险之间的关联。
本研究共纳入240例匹配的病例和对照，研究对象选自马来西亚口腔癌数据库和组织库系统（MOCDTBS）。分别采用高效液相色谱法（HPLC）和食物频率问卷（FFQ）检测视黄醇、α-生育酚和β-胡萝卜素的水平及摄入量。
发现所采用的两种方法的结果不相关，因此使用血清的HPLC方法进行了进一步分析。病例组血清视黄醇和α-生育酚水平（0.177±0.081，1.649±1.670μg/ml）显著低于对照组（0.264±0.137，3.225±2.054μg/ml）（p<0.005）。虽然病例组血清β-胡萝卜素水平（0.106±0.159μg/ml）低于对照组（0.134±0.131μg/ml），但未观察到统计学意义。逻辑回归分析表明，血清视黄醇水平高（OR=0.501，95%CI=0.254-0.992，p<0.05）和α-生育酚水平高（OR=0.184，95%CI=0.091-0.370，p<0.05）与口腔癌风险降低显著相关，而β-胡萝卜素与口腔癌风险之间未观察到相关性。
血清视黄醇和α-生育酚水平高可预防口腔癌风险。
