Liang Dong, Lin Jie, Grossman H Barton, Ma Jing, Wei Bo, Dinney Colin P, Wu Xifeng
Department of Pharmaceutical Sciences, Texas Southern University, Houston, TX, USA.
Cancer Causes Control. 2008 Nov;19(9):981-92. doi: 10.1007/s10552-008-9165-2. Epub 2008 May 14.
Current results on the association between serum micronutrients and bladder cancer risk have been inconsistent. We assessed plasma vitamin E (alpha-tocopherol, and gamma-tocopherol), vitamin A (retinol), and bladder cancer risk using data collected from a case-control study.
Epidemiologic data were collected via in-person interview. Plasma concentrations of alpha-tocopherol, gamma-tocopherol, and retinol were determined by a high-performance liquid chromatography assay. Multivariate logistic regression analyses were used to estimate bladder cancer risk in association with plasma vitamins E and A.
386 bladder cancer patients and 389 age-, gender-, and ethnicity-matched controls were included in the study. The mean plasma alpha-tocopherol and retinol were significantly lower in cases than in controls (alpha-tocopherol: 23.93 microg/ml vs. 27.48 microg/ml, P < 0.001; retinol: 1.41 microg/ml vs. 1.53 microg/ml, P < 0.001). There was a significant reduction in bladder cancer risk associated with increasing plasma alpha-tocopherol level (Adjusted OR: 0.91; 95% CI: 0.85-0.97). In quartile analysis, using subjects with the lowest alpha-tocopherol level as the reference group, the adjusted ORs and 95% CIs for the second, third, and fourth quartiles were 0.75 (0.50-1.14), 0.69 (0.46-1.05), and 0.50 (0.32-0.78), respectively (P for trend = 0.003). Increased retinol level was also associated with reduced risk with OR of 0.57 (95% CI: 0.40-0.81). The ORs and 95% CIs for the second, third, and fourth quartiles were 0.92 (0.61-1.39), 0.66 (0.43-1.01), and 0.62 (0.40-0.95), respectively, with significant dose-response trend (P for trend = 0.01). Finally, there were significant correlations between plasma levels and dietary intakes for the three micronutrients.
Our results suggest potential protective effect of alpha-tocopherol and retinol on bladder cancer risk. Future large prospective studies are needed to confirm the findings.
目前关于血清微量营养素与膀胱癌风险之间关联的研究结果并不一致。我们利用一项病例对照研究收集的数据，评估了血浆维生素E（α-生育酚和γ-生育酚）、维生素A（视黄醇）与膀胱癌风险之间的关系。
通过面对面访谈收集流行病学数据。采用高效液相色谱法测定血浆中α-生育酚、γ-生育酚和视黄醇的浓度。运用多因素逻辑回归分析来评估血浆维生素E和A与膀胱癌风险的关联。
该研究纳入了386例膀胱癌患者和389例年龄、性别及种族匹配的对照。病例组血浆α-生育酚和视黄醇的平均水平显著低于对照组（α-生育酚：23.93微克/毫升对27.48微克/毫升，P<0.001；视黄醇：1.41微克/毫升对1.53微克/毫升，P<0.001）。血浆α-生育酚水平升高与膀胱癌风险显著降低相关（调整后的比值比：0.91；95%置信区间：0.85 - 0.97）。在四分位数分析中，以α-生育酚水平最低的受试者作为参照组，第二、第三和第四四分位数的调整后比值比及95%置信区间分别为0.75（0.50 - 1.14）、0.69（0.46 - 1.05）和0.50（0.32 - 0.78）（趋势P值 = 0.003）。视黄醇水平升高也与风险降低相关，比值比为0.57（95%置信区间：0.40 - 0.81）。第二、第三和第四四分位数的比值比及95%置信区间分别为0.92（0.61 - 1.39）、0.66（0.43 - 1.01）和0.62（0.40 - 0.95），具有显著的剂量反应趋势（趋势P值 = 0.01）。最后，三种微量营养素的血浆水平与膳食摄入量之间存在显著相关性。
我们的研究结果表明α-生育酚和视黄醇对膀胱癌风险可能具有保护作用。未来需要开展大规模的前瞻性研究来证实这些发现。
