Lipton Richard B, Pavlovic Jelena M, Haut Sheryl R, Grosberg Brian M, Buse Dawn C
Departments of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Departments of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA; Montefiore Headache Center, Bronx, NY, USA.
Headache. 2014 Nov-Dec;54(10):1661-9. doi: 10.1111/head.12464. Epub 2014 Oct 23.
In this review, we focus on migraine as a chronic disorder with episodic attacks (CDEA). We aim to review methodological approaches to studying trigger factors and premonitory features that often precede a migraine attack.
Migraine attacks are sometimes initiated by trigger factors, exposures which increase the probability of an attack. They are heralded by premonitory features, symptoms which warn of an impending attack.
DESIGN/METHODS: We review candidate predictors of migraine attack and discuss the methodological issues and approaches to studying attack prediction and suggest that electronic diaries may be the method of choice.
Establishing the relationship between antecedent events and headaches is a formidable challenge. Successfully addressing this challenge should provide insights into disease mechanisms and lead to new strategies for treatment. In the second paper in this series, we review the available literature on trigger factors and premonitory features.
在本综述中，我们聚焦于偏头痛这一具有发作性发作的慢性疾病（CDEA）。我们旨在回顾研究触发因素和常在偏头痛发作前出现的先兆特征的方法学途径。
偏头痛发作有时由触发因素引发，即增加发作概率的暴露因素。发作前会出现先兆特征，即警告即将发作的症状。
设计/方法：我们回顾偏头痛发作的候选预测因素，讨论研究发作预测的方法学问题和途径，并提出电子日记可能是首选方法。
确立前驱事件与头痛之间的关系是一项艰巨的挑战。成功应对这一挑战应能深入了解疾病机制并催生新的治疗策略。在本系列的第二篇论文中，我们将回顾关于触发因素和先兆特征的现有文献。
