Montalo J, Funder J W, Yong A B, Callan A, Davies H E, Connelly J F
Department of Clinical Biochemistry, Royal Children's Hospital, Melbourne, Australia.
J Steroid Biochem. 1989;34(1-6):531-4. doi: 10.1016/0022-4731(89)90139-8.
Serum sulphates of 5-androstene-3 beta, 17 beta-diol (5-ADIOL-S), 5 alpha-androstane-3 alpha,17 beta-diol (3 alpha-DIOL-S) and dehydroepiandrosterone (DHEA-S), as well as unconjugated androstenedione (AD), testosterone (T) and 17 alpha-hydroxyprogesterone (17OHP), sex hormone binding globulin (SHBG) and the free androgen index (FAI) were measured by specific radioimmunoassay in girls with premature adrenarche (n = 9-16), and in hirsute women with (1) late onset 21 hydroxylase deficiency (n = 14), (2) polycystic ovarian disease (n = 28) and (3) idiopathic hirsutism (n = 74). Levels were also determined in females with androgenic alopecia (n = 35-45), in normal prepubertal girls (n = 9-14) and in normal adult women (n = 50-73). Mean serum concentrations of 5-ADIOL-S, 3 alpha-DIOL-S, DHEA-S, AD, T, and FAI were elevated and SHBG depressed, in all patient groups compared with controls, except for DHEA-S and T in patients with alopecia. We conclude that in addition to DHEA-S, 5-ADIOL-S may have a role as a pro-hormone in the synthesis of more potent androgens (T, DHT) in peripheral tissues such as skin; in addition, 3 alpha-DIOL-S may be a marker of peripheral androgen metabolism.
采用特异性放射免疫分析法，测定了9至16例肾上腺功能早现女孩、14例迟发型21羟化酶缺乏的多毛女性、28例多囊卵巢疾病患者以及74例特发性多毛症患者血清中5-雄烯二醇-3β，17β-二硫酸酯（5-ADIOL-S）、5α-雄烷二醇-3α，17β-二硫酸酯（3α-DIOL-S）、脱氢表雄酮（DHEA-S）、游离雄烯二酮（AD）、睾酮（T）、17α-羟孕酮（17OHP）、性激素结合球蛋白（SHBG）以及游离雄激素指数（FAI）的水平。同时，还测定了35至45例雄激素性脱发女性、9至14例正常青春前期女孩以及50至73例正常成年女性的上述指标。与对照组相比，除脱发患者的DHEA-S和T外，所有患者组的5-ADIOL-S、3α-DIOL-S、DHEA-S、AD、T以及FAI的血清平均浓度均升高，而SHBG降低。我们得出结论，除DHEA-S外，5-ADIOL-S可能作为一种前体激素，在外周组织如皮肤中参与合成更强效的雄激素（T、双氢睾酮）；此外，3α-DIOL-S可能是外周雄激素代谢的一个标志物。
