Borodin Yu I, Lomshakov A A, Astashov V V, Kazakov O V, Mayorov A P, Larionov P M
Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2014 Oct;157(6):724-7. doi: 10.1007/s10517-014-2652-4. Epub 2014 Oct 24.
We studied structural changes in the prostate gland, thymus, and lymph nodes in CBA mice after transplantation of Ehrlich ascites tumor cells into the prostate gland. On experimental day 5, the number of blood and lymph vessels decreased in the gland; the percentage of connective tissue elements and glandular tissue and the number of immunoblasts in the thymus increased. On day 18, the number of blood vessels in the tumor decreased; the width of the cortex and glandular tissue increased in the thymus, while the number of immunoblasts was reduced. On day 28, tumor infiltration and increased number of lymphatic vessels in its stroma were observed; parenchyma was reduced, and the area of the connective tissue increased in the thymus. These structural changes indicated the development of accidental involution of the thymus during carcinogenesis of the prostate.
我们研究了将艾氏腹水瘤细胞移植到前列腺后CBA小鼠前列腺、胸腺和淋巴结的结构变化。实验第5天，前列腺内血管和淋巴管数量减少；胸腺中结缔组织成分、腺组织的百分比以及免疫母细胞数量增加。第18天，肿瘤内血管数量减少；胸腺皮质和腺组织宽度增加，而免疫母细胞数量减少。第28天，观察到肿瘤浸润及其基质中淋巴管数量增加；胸腺实质减少，结缔组织面积增加。这些结构变化表明前列腺癌发生过程中胸腺出现了意外萎缩。
