Sonka K, Roth B, Barvírová H, Nevsímal O
Neurological Clinic, Faculty of Medicine, Charles University, Prague.
Physiol Bohemoslov. 1989;38(5):477-9.
A simple blind study with small doses of naloxone (0.8-1.6 mg i.v.) was carried out in 11 patients with hypersomnia with sleep apnoea (HSA). The effect was studied by diurnal polysomnography. It was found that the administration of naloxone was followed by significant prolongation of wakefulness and by significant shortening of the total duration of the second stage of NREM sleep. The duration of the apnoeic episodes was also significantly shortened after naloxone, although their number did not alter. Increased activity of the endorphinergic system (which naloxone inhibits by receptor competition) evidently plays a role in the pathophysiology of HSA.
对11例患有睡眠呼吸暂停的发作性睡病（HSA）患者进行了一项使用小剂量纳洛酮（静脉注射0.8 - 1.6毫克）的简单盲法研究。通过日间多导睡眠图研究其效果。发现给予纳洛酮后，清醒时间显著延长，非快速眼动睡眠第二阶段的总时长显著缩短。纳洛酮使用后呼吸暂停发作的时长也显著缩短，但其发作次数没有改变。内啡肽能系统活性增加（纳洛酮通过受体竞争抑制该系统）显然在HSA的病理生理学中起作用。
