Sonka K, Roth B, Posmurová M
Agressologie. 1989 Feb;30(2):93-6.
The effect of Naloxone (0.4 mg i.v.) was studied in 10 patients suffering from narcolepsy. The diurnal polysomnographic recordings showed that Naloxone leads to an increase in the latency of REM sleep (P less than 0.05), to a shortening of its total duration and to a decrease in the average amount of phasic manifestations in 1 min. of REM sleep (P less than 0.05). The Polygraphic sleepiness score for REM sleep decreased significantly (P less than 0.01). Naloxone led also to the disappearance of stages 3 and 4 NREM sleep, and to an increase in the total duration of stage 1 NREM sleep. Naloxone caused no change in the total performance in Bourdon's test; though it did enhance attention. There were no changes in the subjective perception of the state of arousal or of the psychomotor tempo. It was found no post-Naloxone alterations of blood pressure, body temperature, pulse or pupillary diameter. The above findings support the hypothesis that an hyperactive endorphinergic system participates in the pathophysiology of narcolepsy.
对10名发作性睡病患者研究了纳洛酮（静脉注射0.4毫克）的作用。昼夜多导睡眠图记录显示，纳洛酮可导致快速眼动睡眠潜伏期延长（P<0.05），其总时长缩短，且快速眼动睡眠1分钟内的相位表现平均数量减少（P<0.05）。快速眼动睡眠的多导睡眠嗜睡评分显著降低（P<0.01）。纳洛酮还导致非快速眼动睡眠3期和4期消失，并使非快速眼动睡眠1期的总时长增加。纳洛酮对布尔东测试的总体表现没有影响；不过它确实增强了注意力。在觉醒状态或精神运动速度的主观感知方面没有变化。未发现纳洛酮给药后血压、体温、脉搏或瞳孔直径有改变。上述发现支持了内源性阿片肽系统功能亢进参与发作性睡病病理生理学的假说。
