Heuberger R, Wahl P, Krieg J, Gautier E
RMS Foundation, Bischmattstr 12, CH-2544 Bettlach,
Eur Cell Mater. 2014 Oct 23;28:246-57. doi: 10.22203/ecm.v028a17.
In case of implant associated infection, implant preservation is associated with high failure rates. Therefore, a removal or exchange of the implant is most often mandatory for treatment success. Alternatively, under certain conditions, local antibiotic delivery can be applied - preserving the implant, using for example calcium sulphate as a resorbable carrier. In this work, third-body wear on total hip prostheses caused by calcium sulphate particles was tested in a hip simulator. Inlays made of ultra-high-molecular-weight polyethylene (UHMWPE) and cross-linked polyethylene (XLPE) against 28 mm CoCrMo heads and 36 mm alumina pairings were tested in triplicate, both with and without calcium sulphate particles in the test liquid. Neither the alumina articulations nor the CoCrMo heads were affected by the calcium sulphate particles since calcium sulphate is a relatively soft material. The polyethylene inlays showed 39-89 % higher wear during exposure compared to references, but wear returned to normal when no more particles were added. Thus, calcium sulphate might be used as antibiotic carrier even in the presence of total hip prostheses without fearing excessive third-body wear.
在植入物相关感染的情况下，保留植入物与高失败率相关。因此，为了治疗成功，通常必须移除或更换植入物。或者，在某些条件下，可以应用局部抗生素递送——保留植入物，例如使用硫酸钙作为可吸收载体。在这项工作中，在髋关节模拟器中测试了硫酸钙颗粒对全髋关节假体的三体磨损。由超高分子量聚乙烯（UHMWPE）和交联聚乙烯（XLPE）制成的镶嵌物与28毫米钴铬钼（CoCrMo）股骨头和36毫米氧化铝配对物进行了三次测试，测试液体中有无硫酸钙颗粒。由于硫酸钙是一种相对柔软的材料，氧化铝关节和钴铬钼股骨头均未受到硫酸钙颗粒的影响。与对照相比，聚乙烯镶嵌物在暴露期间的磨损高出39%至89%，但当不再添加颗粒时，磨损恢复正常。因此，即使在存在全髋关节假体的情况下，硫酸钙也可作为抗生素载体使用，而无需担心过度的三体磨损。
